TY  - JOUR
  - Dinan, TG,O'Brien, S,Lavelle, E,Scott, LV
  - 2004
  - January
  - International Journal of Psychological Medicine
  - Further neuroendocrine evidence of enhanced vasopressin V-3 receptor responses in melancholic depression
  - Validated
  - ()
  - CORTICOTROPIN-RELEASING HORMONE PITUITARY-ADRENAL AXIS MAJOR DEPRESSION HEALTHY-SUBJECTS GLUCOCORTICOIDS PATHOPHYSIOLOGY DISORDERS INCREASE STRESS PLASMA
  - 34
  - 169
  - 172
  - Background. In situations of chronic stress vasopressin plays an important role in regulating the hypothalamic-pituitary-adrenal axis. The aim of the current study was to investigate the role of anterior pituitary vasopressin V-3 receptors in maintaining the hypercortisolism seen in melancholic depression.Method. Fourteen patients with major depression and 14 age- and sex-matched healthy comparison subjects were recruited. Desmopressin (ddAVP) 10 mug was given intravenously and ACTH and cortisol release was monitored for 120 min.Results. The mean +/- S.E.M. ACTH response in the depressives was 28(.)4 +/- 4(.)3 ng/l and in the healthy subjects was 18(.)8 +/- 4(.)9 ng/l (P = 0(.)04). The mean +/- S.E.M. cortisol response in the depressives was 261(.)8 +/- 46(.)5 nmol/l and in the healthy subjects was 107(.)3 +/- 26(.)1 nmol/l (P < 0(.)01).Conclusions. Patients with major depression have augmented ACTH and cortisol responses to desmopressin indicating enhanced V-3 responsivity.
  - DOI 10.1017/S0033291703001004
DA  - 2004/01
ER  - 

@article{V43337434,
   = {Dinan,  TG and O'Brien,  S and Lavelle,  E and Scott,  LV },
   = {2004},
   = {January},
   = {International Journal of Psychological Medicine},
   = {Further neuroendocrine evidence of enhanced vasopressin V-3 receptor responses in melancholic depression},
   = {Validated},
   = {()},
   = {CORTICOTROPIN-RELEASING HORMONE PITUITARY-ADRENAL AXIS MAJOR DEPRESSION HEALTHY-SUBJECTS GLUCOCORTICOIDS PATHOPHYSIOLOGY DISORDERS INCREASE STRESS PLASMA},
   = {34},
  pages = {169--172},
   = {{Background. In situations of chronic stress vasopressin plays an important role in regulating the hypothalamic-pituitary-adrenal axis. The aim of the current study was to investigate the role of anterior pituitary vasopressin V-3 receptors in maintaining the hypercortisolism seen in melancholic depression.Method. Fourteen patients with major depression and 14 age- and sex-matched healthy comparison subjects were recruited. Desmopressin (ddAVP) 10 mug was given intravenously and ACTH and cortisol release was monitored for 120 min.Results. The mean +/- S.E.M. ACTH response in the depressives was 28(.)4 +/- 4(.)3 ng/l and in the healthy subjects was 18(.)8 +/- 4(.)9 ng/l (P = 0(.)04). The mean +/- S.E.M. cortisol response in the depressives was 261(.)8 +/- 46(.)5 nmol/l and in the healthy subjects was 107(.)3 +/- 26(.)1 nmol/l (P < 0(.)01).Conclusions. Patients with major depression have augmented ACTH and cortisol responses to desmopressin indicating enhanced V-3 responsivity.}},
   = {DOI 10.1017/S0033291703001004},
  source = {IRIS}
}