IRIS publication 722684
Increased Tumor Necrosis Factor-Alpha Concentrations With Interleukin-4 Concentrations In Exacerbations of Schizophrenia
RIS format for Endnote and similar
TY - JOUR - O'Brien, SM, Scully, P, Dinan, TG - 2008 - August - Psychiatry Research - Increased Tumor Necrosis Factor-Alpha Concentrations With Interleukin-4 Concentrations In Exacerbations of Schizophrenia - Validated - () - 160 - 3 - 256 - 262 - Several studies have indicated that cytokines may be involved in the pathophysiology of schizophrenia. Previous studies, however, have yielded contradictory results; in this study we assess the plasma levels of both T-helper-1 (Th 1) and T-helper-2 (Th2) cytokines in patients with acute exacerbations of schizophrenia. Plasma concentrations of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha) and soluble receptor of interleukin-6 (sIL-6R) were measured with high sensitivity, enzyme-linked immunosorbent assays (ELISA) in patients with acute exacerbations of schizophrenia as compared with healthy controls. Patients with an acute exacerbation of schizophrenia had significantly increased production of TNF-alpha and significantly reduced production of IL-4 as compared with healthy subjects. No significant difference was observed in IL-6, sIL-6R, IL-8 and IL-10. Acute exacerbations of schizophrenia are associated with increased TNF-alpha concentrations (Th1) with concomitantly reduced concentrations of IL-4 (Th2) and a resulting increased TNF-alpha/IL-4 ratio. (C) 2007 Elsevier Ireland Ltd. All rights reserved.. - DOI 10.1016/j.psychres.2007.11.014 DA - 2008/08 ER -
BIBTeX format for JabRef and similar
@article{V722684, = {O'Brien, SM and Scully, P and Dinan, TG }, = {2008}, = {August}, = {Psychiatry Research}, = {Increased Tumor Necrosis Factor-Alpha Concentrations With Interleukin-4 Concentrations In Exacerbations of Schizophrenia}, = {Validated}, = {()}, = {160}, = {3}, pages = {256--262}, = {{Several studies have indicated that cytokines may be involved in the pathophysiology of schizophrenia. Previous studies, however, have yielded contradictory results; in this study we assess the plasma levels of both T-helper-1 (Th 1) and T-helper-2 (Th2) cytokines in patients with acute exacerbations of schizophrenia. Plasma concentrations of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha) and soluble receptor of interleukin-6 (sIL-6R) were measured with high sensitivity, enzyme-linked immunosorbent assays (ELISA) in patients with acute exacerbations of schizophrenia as compared with healthy controls. Patients with an acute exacerbation of schizophrenia had significantly increased production of TNF-alpha and significantly reduced production of IL-4 as compared with healthy subjects. No significant difference was observed in IL-6, sIL-6R, IL-8 and IL-10. Acute exacerbations of schizophrenia are associated with increased TNF-alpha concentrations (Th1) with concomitantly reduced concentrations of IL-4 (Th2) and a resulting increased TNF-alpha/IL-4 ratio. (C) 2007 Elsevier Ireland Ltd. All rights reserved..}}, = {DOI 10.1016/j.psychres.2007.11.014}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | O'Brien, SM, Scully, P, Dinan, TG | ||
YEAR | 2008 | ||
MONTH | August | ||
JOURNAL_CODE | Psychiatry Research | ||
TITLE | Increased Tumor Necrosis Factor-Alpha Concentrations With Interleukin-4 Concentrations In Exacerbations of Schizophrenia | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | |||
VOLUME | 160 | ||
ISSUE | 3 | ||
START_PAGE | 256 | ||
END_PAGE | 262 | ||
ABSTRACT | Several studies have indicated that cytokines may be involved in the pathophysiology of schizophrenia. Previous studies, however, have yielded contradictory results; in this study we assess the plasma levels of both T-helper-1 (Th 1) and T-helper-2 (Th2) cytokines in patients with acute exacerbations of schizophrenia. Plasma concentrations of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha) and soluble receptor of interleukin-6 (sIL-6R) were measured with high sensitivity, enzyme-linked immunosorbent assays (ELISA) in patients with acute exacerbations of schizophrenia as compared with healthy controls. Patients with an acute exacerbation of schizophrenia had significantly increased production of TNF-alpha and significantly reduced production of IL-4 as compared with healthy subjects. No significant difference was observed in IL-6, sIL-6R, IL-8 and IL-10. Acute exacerbations of schizophrenia are associated with increased TNF-alpha concentrations (Th1) with concomitantly reduced concentrations of IL-4 (Th2) and a resulting increased TNF-alpha/IL-4 ratio. (C) 2007 Elsevier Ireland Ltd. All rights reserved.. | ||
PUBLISHER_LOCATION | |||
ISBN_ISSN | |||
EDITION | |||
URL | |||
DOI_LINK | DOI 10.1016/j.psychres.2007.11.014 | ||
FUNDING_BODY | |||
GRANT_DETAILS |