TY  - JOUR
  - O'Mahony, SM; Bulmer, DC; Coelho, AM; Fitzgerald, P; Bongiovanni, C; Lee, K; Winchester, W; Dinan, TG; Cryan, JF
  - 2009
  - December
  - Neurogastroenterology and Motility
  - 5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction.
  - Validated
  - WOS: 52 ()
  - Irritable bowel syndrome (IBS) is associated with an enhanced perception to visceral stimuli and exaggerated stress response. The serotonergic neurotransmitter system has been strongly implicated as a key player in the manifestation of IBS symptomatology including visceral hypersensitivity. However the role of 5-HT(2B) receptors in visceral pain, although speculated, is currently unclear. Thus we assessed the impact of a selective 5-HT(2B) receptor antagonist, RS-127445, on visceral hypersensitivity in a model of brain gut axis dysfunction the Wistar Kyoto (WKY) rat.
  - 10.1111/j.1365-2982.2009.01432.x
DA  - 2009/12
ER  - 

@article{V8985863,
   = {O'Mahony, SM and  Bulmer, DC and  Coelho, AM and  Fitzgerald, P and  Bongiovanni, C and  Lee, K and  Winchester, W and  Dinan, TG and  Cryan, JF},
   = {2009},
   = {December},
   = {Neurogastroenterology and Motility},
   = {5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction.},
   = {Validated},
   = {WOS: 52 ()},
   = {{Irritable bowel syndrome (IBS) is associated with an enhanced perception to visceral stimuli and exaggerated stress response. The serotonergic neurotransmitter system has been strongly implicated as a key player in the manifestation of IBS symptomatology including visceral hypersensitivity. However the role of 5-HT(2B) receptors in visceral pain, although speculated, is currently unclear. Thus we assessed the impact of a selective 5-HT(2B) receptor antagonist, RS-127445, on visceral hypersensitivity in a model of brain gut axis dysfunction the Wistar Kyoto (WKY) rat.}},
   = {10.1111/j.1365-2982.2009.01432.x},
  source = {IRIS}
}