TY  - JOUR
  - Cashman, KD, Hill, TR, Lucey, AJ, Taylor, N, Seamans, KM, Muldowney, S, FitzGerald, AP, Flynn, A, Barnes, MS, Horigan, G, Bonham, MP, Duffy, EM, Strain, JJ, Wallace, JMW, Kiely, M
  - 2008
  - August
  - The American Journal of Clinical Nutrition
  - Estimation of The Dietary Requirement For Vitamin D In Healthy Adults
  - Validated
  - ()
  - 88
  - 6
  - 1535
  - 1542
  - Background: Knowledge gaps have contributed to considerable variation among international dietary recommendations for vitamin D. Objective: We aimed to establish the distribution of dietary vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH) D] concentrations above several proposed cutoffs (ie, 25, 37.5, 50, and 80 nmol/L) during wintertime after adjustment for the effect of summer sunshine exposure and diet. Design: A randomized, placebo-controlled, double-blind 22-wk intervention study was conducted in men and women aged 20-40 y (n = 238) by using different supplemental doses (0, 5, 10, and 15 mu g/d) of vitamin D 3 throughout the winter. Serum 25(OH) D concentrations were measured by using enzyme-linked immunoassay at baseline (October 2006) and endpoint (March 2007). Results: There were clear dose-related increments (P < 0.0001) in serum 25(OH) D with increasing supplemental vitamin D-3. The slope of the relation between vitamin D intake and serum 25(OH) D was 1.96 nmol.L-1.mu g(-1) intake. The vitamin D intake that maintained serum 25(OH) D concentrations of >25 nmol/L in 97.5% of the sample was 8.7 mu g/d. This intake ranged from 7.2 mu g/d in those who enjoyed sunshine exposure, 8.8 mu g/d in those who sometimes had sun exposure, and 12.3 mu g/d in those who avoided sunshine. Vitamin D intakes required to maintain serum 25(OH) D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 19.9, 28.0, and 41.1 mu g/d, respectively. Conclusion: The range of vitamin D intakes required to ensure maintenance of wintertime vitamin D status [as defined by incremental cutoffs of serum 25(OH) D] in the vast majority (>97.5%) of 20-40-y-old adults, considering a variety of sun exposure preferences, is between 7.2 and 41.1 mu g/d. Am J Clin Nutr 2008; 88: 1535-42..
  - DOI 10.3945/ajcn.2008.26594
DA  - 2008/08
ER  - 

@article{V722014,
   = {Cashman,  KD and  Hill,  TR and  Lucey,  AJ and  Taylor,  N and  Seamans,  KM and  Muldowney,  S and  FitzGerald,  AP and  Flynn,  A and  Barnes,  MS and  Horigan,  G and  Bonham,  MP and  Duffy,  EM and  Strain,  JJ and  Wallace,  JMW and  Kiely,  M },
   = {2008},
   = {August},
   = {The American Journal of Clinical Nutrition},
   = {Estimation of The Dietary Requirement For Vitamin D In Healthy Adults},
   = {Validated},
   = {()},
   = {88},
   = {6},
  pages = {1535--1542},
   = {{Background: Knowledge gaps have contributed to considerable variation among international dietary recommendations for vitamin D. Objective: We aimed to establish the distribution of dietary vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH) D] concentrations above several proposed cutoffs (ie, 25, 37.5, 50, and 80 nmol/L) during wintertime after adjustment for the effect of summer sunshine exposure and diet. Design: A randomized, placebo-controlled, double-blind 22-wk intervention study was conducted in men and women aged 20-40 y (n = 238) by using different supplemental doses (0, 5, 10, and 15 mu g/d) of vitamin D 3 throughout the winter. Serum 25(OH) D concentrations were measured by using enzyme-linked immunoassay at baseline (October 2006) and endpoint (March 2007). Results: There were clear dose-related increments (P < 0.0001) in serum 25(OH) D with increasing supplemental vitamin D-3. The slope of the relation between vitamin D intake and serum 25(OH) D was 1.96 nmol.L-1.mu g(-1) intake. The vitamin D intake that maintained serum 25(OH) D concentrations of >25 nmol/L in 97.5% of the sample was 8.7 mu g/d. This intake ranged from 7.2 mu g/d in those who enjoyed sunshine exposure, 8.8 mu g/d in those who sometimes had sun exposure, and 12.3 mu g/d in those who avoided sunshine. Vitamin D intakes required to maintain serum 25(OH) D concentrations of >37.5, >50, and >80 nmol/L in 97.5% of the sample were 19.9, 28.0, and 41.1 mu g/d, respectively. Conclusion: The range of vitamin D intakes required to ensure maintenance of wintertime vitamin D status [as defined by incremental cutoffs of serum 25(OH) D] in the vast majority (>97.5%) of 20-40-y-old adults, considering a variety of sun exposure preferences, is between 7.2 and 41.1 mu g/d. Am J Clin Nutr 2008; 88: 1535-42..}},
   = {DOI 10.3945/ajcn.2008.26594},
  source = {IRIS}
}