Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase

Typeset version

 

TY  - JOUR
  - Paruch, K.,Dwyer, M. P.,Alvarez, C.,Brown, C.,Chan, T. Y.,Doll, R. J.,Keertikar, K.,Knutson, C.,McKittrick, B.,Rivera, J.,Rossman, R.,Tucker, G.,Fischmann, T. O.,Hruza, A.,Madison, V.,Nomeir, A. A.,Wang, Y. L.,Lees, E.,Parry, D.,Sgambellone, N.,Seghezzi, W.,Schultz, L.,Shanahan, F.,Wiswell, D.,Xu, X. Y.,Zhou, Q.,James, R. A.,Paradkar, V. M.,Park, H.,Rokosz, L. R.,Stauffer, T. M.,Guzi, T. J.
  - 2007
  - November
  - Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase
  - Validated
  - ()
  - 17
  - 2222
  - 6220
  - 62236220
  - Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.
  - 0960-894X0960-894X
  - ://WOS:000250906200036://WOS:000250906200036
DA  - 2007/11
ER  - 
@article{V235379239,
   = {Paruch,  K. and Dwyer,  M. P. and Alvarez,  C. and Brown,  C. and Chan,  T. Y. and Doll,  R. J. and Keertikar,  K. and Knutson,  C. and McKittrick,  B. and Rivera,  J. and Rossman,  R. and Tucker,  G. and Fischmann,  T. O. and Hruza,  A. and Madison,  V. and Nomeir,  A. A. and Wang,  Y. L. and Lees,  E. and Parry,  D. and Sgambellone,  N. and Seghezzi,  W. and Schultz,  L. and Shanahan,  F. and Wiswell,  D. and Xu,  X. Y. and Zhou,  Q. and James,  R. A. and Paradkar,  V. M. and Park,  H. and Rokosz,  L. R. and Stauffer,  T. M. and Guzi,  T. J. },
   = {2007},
   = {November},
   = {Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase},
   = {Validated},
   = {()},
   = {17},
   = {2222},
  pages = {6220--62236220},
   = {{Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.}},
  issn = {0960-894X0960-894X},
   = {://WOS:000250906200036://WOS:000250906200036},
  source = {IRIS}
}
AUTHORSParuch, K.,Dwyer, M. P.,Alvarez, C.,Brown, C.,Chan, T. Y.,Doll, R. J.,Keertikar, K.,Knutson, C.,McKittrick, B.,Rivera, J.,Rossman, R.,Tucker, G.,Fischmann, T. O.,Hruza, A.,Madison, V.,Nomeir, A. A.,Wang, Y. L.,Lees, E.,Parry, D.,Sgambellone, N.,Seghezzi, W.,Schultz, L.,Shanahan, F.,Wiswell, D.,Xu, X. Y.,Zhou, Q.,James, R. A.,Paradkar, V. M.,Park, H.,Rokosz, L. R.,Stauffer, T. M.,Guzi, T. J.
YEAR2007
MONTHNovember
JOURNAL_CODE
TITLEPyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORD
VOLUME17
ISSUE2222
START_PAGE6220
END_PAGE62236220
ABSTRACTProperly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.
PUBLISHER_LOCATION
ISBN_ISSN0960-894X0960-894X
EDITION
URL://WOS:000250906200036://WOS:000250906200036
DOI_LINK
FUNDING_BODY
GRANT_DETAILS