IRIS publication 235379239
Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase
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TY - JOUR - Paruch, K.,Dwyer, M. P.,Alvarez, C.,Brown, C.,Chan, T. Y.,Doll, R. J.,Keertikar, K.,Knutson, C.,McKittrick, B.,Rivera, J.,Rossman, R.,Tucker, G.,Fischmann, T. O.,Hruza, A.,Madison, V.,Nomeir, A. A.,Wang, Y. L.,Lees, E.,Parry, D.,Sgambellone, N.,Seghezzi, W.,Schultz, L.,Shanahan, F.,Wiswell, D.,Xu, X. Y.,Zhou, Q.,James, R. A.,Paradkar, V. M.,Park, H.,Rokosz, L. R.,Stauffer, T. M.,Guzi, T. J. - 2007 - November - Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase - Validated - () - 17 - 2222 - 6220 - 62236220 - Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved. - 0960-894X0960-894X - ://WOS:000250906200036://WOS:000250906200036 DA - 2007/11 ER -
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@article{V235379239, = {Paruch, K. and Dwyer, M. P. and Alvarez, C. and Brown, C. and Chan, T. Y. and Doll, R. J. and Keertikar, K. and Knutson, C. and McKittrick, B. and Rivera, J. and Rossman, R. and Tucker, G. and Fischmann, T. O. and Hruza, A. and Madison, V. and Nomeir, A. A. and Wang, Y. L. and Lees, E. and Parry, D. and Sgambellone, N. and Seghezzi, W. and Schultz, L. and Shanahan, F. and Wiswell, D. and Xu, X. Y. and Zhou, Q. and James, R. A. and Paradkar, V. M. and Park, H. and Rokosz, L. R. and Stauffer, T. M. and Guzi, T. J. }, = {2007}, = {November}, = {Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase}, = {Validated}, = {()}, = {17}, = {2222}, pages = {6220--62236220}, = {{Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.}}, issn = {0960-894X0960-894X}, = {://WOS:000250906200036://WOS:000250906200036}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Paruch, K.,Dwyer, M. P.,Alvarez, C.,Brown, C.,Chan, T. Y.,Doll, R. J.,Keertikar, K.,Knutson, C.,McKittrick, B.,Rivera, J.,Rossman, R.,Tucker, G.,Fischmann, T. O.,Hruza, A.,Madison, V.,Nomeir, A. A.,Wang, Y. L.,Lees, E.,Parry, D.,Sgambellone, N.,Seghezzi, W.,Schultz, L.,Shanahan, F.,Wiswell, D.,Xu, X. Y.,Zhou, Q.,James, R. A.,Paradkar, V. M.,Park, H.,Rokosz, L. R.,Stauffer, T. M.,Guzi, T. J. | ||
YEAR | 2007 | ||
MONTH | November | ||
JOURNAL_CODE | |||
TITLE | Pyrazolo[1,5-alpha]pyrimidines as orally available inhibitors of cyclin-dependent kinase | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | |||
VOLUME | 17 | ||
ISSUE | 2222 | ||
START_PAGE | 6220 | ||
END_PAGE | 62236220 | ||
ABSTRACT | Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved. | ||
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ISBN_ISSN | 0960-894X0960-894X | ||
EDITION | |||
URL | ://WOS:000250906200036://WOS:000250906200036 | ||
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