TY  - JOUR
  - Duggan, P.,O'Brien, M.,Kiely, M.,McCarthy, J.,Shanahan, F.,Cashman, K. D.
  - 2004
  - November
  - American Journal of Gastroenterology
  - Vitamin K status in patients with Crohn's disease and relationship to bone turnover
  - Validated
  - ()
  - 99
  - 11
  - 2178
  - 2185
  - BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.
  - 0002-92700002-9270
  - ://WOS:000224767900019://WOS:000224767900019
DA  - 2004/11
ER  - 

@article{V235379422,
   = {Duggan,  P. and O'Brien,  M. and Kiely,  M. and McCarthy,  J. and Shanahan,  F. and Cashman,  K. D. },
   = {2004},
   = {November},
   = {American Journal of Gastroenterology},
   = {Vitamin K status in patients with Crohn's disease and relationship to bone turnover},
   = {Validated},
   = {()},
   = {99},
   = {11},
  pages = {2178--2185},
   = {{BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.BACKGROUND: There is a high prevalence of osteopenia among patients with Crohn's disease (CD). There is some evidence that a deficiency of certain bone-active nutrients (including vitamins K and D) may have a partial role in this bone loss. AIMS: To compare the intake and the status of vitamin K in CD patients, currently in remission, with age and sex-matched controls, and furthermore to investigate the relationship between vitamin K status and bone turnover in these patients. SUBJECTS: CD patients (n = 44; mean age: 36.9 yr) and matched controls (n = 44) were recruited from the Cork University Hospital and Cork City area, respectively. METHODS: Bloods were analyzed for the total and undercarboxylated (Glu)-osteocalcin and urine analyzed for cross-linked N-telopeptides of type I collagen (NTx). Vitamin K-1 intake was estimated by food frequency questionnaire. RESULTS: Vitamin K-1 intake in CD patients tended to be lower than that of controls (mean (SD), 117 (82) vs 148 (80) mug/d, respectively; p = 0.059). Glu and NTx concentrations in CD patients were higher than controls (mean (SD), 5.1 (3.1) vs 3.9 (2.1) ng/ml, respectively; p = 0.03 for Glu; and 49 (41) vs 25.8 (19.5) nM BCE/mM creatinine, respectively; p = 0.001 for NTx). In CD patients, Glu was significantly correlated with NTx (r = 0.488; p < 0.001), even after controlling for age, gender, vitamin D status, calcium intake, and corticosteroid use. CONCLUSION: Vitamin K status of CD patients was lower than that of the healthy controls. Furthermore, the rate of bone resorption in the CD was inversely correlated with vitamin K status, suggesting that it might be another etiological factor for CD-related osteopenia.}},
  issn = {0002-92700002-9270},
   = {://WOS:000224767900019://WOS:000224767900019},
  source = {IRIS}
}