TY  - JOUR
  - Cronin, C. C.,Feighery, A.,Ferriss, B.,Liddy, C.,Shanahan, F.,Feighery, C.
  - 1997
  - December
  - High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus
  - Validated
  - ()
  - 92
  - 1212
  - 2210
  - 22122210
  - Objectives: Diagnosis of unrecognized celiac disease is potentially important, The prevalence of celiac disease in patients with insulin-dependent diabetes mellitus is uncertain, We report the prevalence of celiac disease in a stratified random sample (n = 101) of adult insulin-dependent diabetic patients (age, 18-59 yr) attending our clinic, and in an age-and sex-matched control group (n = 51). Methods: Screening was by anti-endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord, Results: Celiac disease had not been suspected in any patient at the time of screening, Eight patients tested positive for anti-endomysial antibody, all of whom had a distal duodenal biopsy performed, Five patients had histologic evidence of celiac disease, One patient with negative histology was receiving immunosuppressive therapy for a renal-pancreas transplant, Of the five patients with abnormal histology, two improved on gluten restriction, one was unable to comply, one refused treatment, and one was lost to follow-up, No control subject tested positive for endomysial antibody, Conclusions: Patients with insulin-dependent diabetes have an increased prevalence of celiac disease. Because most cases are clinically unrecognized consideration should be given to screening all insulin-dependent diabetes mellitus patients with endomysial antibodies.Objectives: Diagnosis of unrecognized celiac disease is potentially important, The prevalence of celiac disease in patients with insulin-dependent diabetes mellitus is uncertain, We report the prevalence of celiac disease in a stratified random sample (n = 101) of adult insulin-dependent diabetic patients (age, 18-59 yr) attending our clinic, and in an age-and sex-matched control group (n = 51). Methods: Screening was by anti-endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord, Results: Celiac disease had not been suspected in any patient at the time of screening, Eight patients tested positive for anti-endomysial antibody, all of whom had a distal duodenal biopsy performed, Five patients had histologic evidence of celiac disease, One patient with negative histology was receiving immunosuppressive therapy for a renal-pancreas transplant, Of the five patients with abnormal histology, two improved on gluten restriction, one was unable to comply, one refused treatment, and one was lost to follow-up, No control subject tested positive for endomysial antibody, Conclusions: Patients with insulin-dependent diabetes have an increased prevalence of celiac disease. Because most cases are clinically unrecognized consideration should be given to screening all insulin-dependent diabetes mellitus patients with endomysial antibodies.
  - 0002-92700002-9270
  - ://WOS:A1997YK23100015://WOS:A1997YK23100015
DA  - 1997/12
ER  - 

@article{V235379876,
   = {Cronin,  C. C. and Feighery,  A. and Ferriss,  B. and Liddy,  C. and Shanahan,  F. and Feighery,  C. },
   = {1997},
   = {December},
   = {High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus},
   = {Validated},
   = {()},
   = {92},
   = {1212},
  pages = {2210--22122210},
   = {{Objectives: Diagnosis of unrecognized celiac disease is potentially important, The prevalence of celiac disease in patients with insulin-dependent diabetes mellitus is uncertain, We report the prevalence of celiac disease in a stratified random sample (n = 101) of adult insulin-dependent diabetic patients (age, 18-59 yr) attending our clinic, and in an age-and sex-matched control group (n = 51). Methods: Screening was by anti-endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord, Results: Celiac disease had not been suspected in any patient at the time of screening, Eight patients tested positive for anti-endomysial antibody, all of whom had a distal duodenal biopsy performed, Five patients had histologic evidence of celiac disease, One patient with negative histology was receiving immunosuppressive therapy for a renal-pancreas transplant, Of the five patients with abnormal histology, two improved on gluten restriction, one was unable to comply, one refused treatment, and one was lost to follow-up, No control subject tested positive for endomysial antibody, Conclusions: Patients with insulin-dependent diabetes have an increased prevalence of celiac disease. Because most cases are clinically unrecognized consideration should be given to screening all insulin-dependent diabetes mellitus patients with endomysial antibodies.Objectives: Diagnosis of unrecognized celiac disease is potentially important, The prevalence of celiac disease in patients with insulin-dependent diabetes mellitus is uncertain, We report the prevalence of celiac disease in a stratified random sample (n = 101) of adult insulin-dependent diabetic patients (age, 18-59 yr) attending our clinic, and in an age-and sex-matched control group (n = 51). Methods: Screening was by anti-endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord, Results: Celiac disease had not been suspected in any patient at the time of screening, Eight patients tested positive for anti-endomysial antibody, all of whom had a distal duodenal biopsy performed, Five patients had histologic evidence of celiac disease, One patient with negative histology was receiving immunosuppressive therapy for a renal-pancreas transplant, Of the five patients with abnormal histology, two improved on gluten restriction, one was unable to comply, one refused treatment, and one was lost to follow-up, No control subject tested positive for endomysial antibody, Conclusions: Patients with insulin-dependent diabetes have an increased prevalence of celiac disease. Because most cases are clinically unrecognized consideration should be given to screening all insulin-dependent diabetes mellitus patients with endomysial antibodies.}},
  issn = {0002-92700002-9270},
   = {://WOS:A1997YK23100015://WOS:A1997YK23100015},
  source = {IRIS}
}