IRIS publication 243940130
Normative levels of Interleukin 16 in umbilical cord blood
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TY - JOUR - Denihan, NM,Looney, AM,Boylan, GB,Walsh, BH,Murray, DM - 2013 - December - Clinical biochemistry - Normative levels of Interleukin 16 in umbilical cord blood - Validated - () - Interleukin 16 Hypoxic-ischaemic encephalopathy Umbilical cord blood Cytokines Vaginal delivery Elective caesarean section Pregnancy ELISA ZEALAND SOCIOECONOMIC INDEX TUMOR-NECROSIS-FACTOR DELIVERY IL-16 EXPRESSION PREECLAMPSIA MONOCYTES MODE - 46 - 1857 - 1859 - Objectives: The need for early and accurate prediction of outcome in hypoxic-ischaemic encephalopathy (HIE) remains critical. We have previously demonstrated that Interleulkin 16 (IL-16) is raised in the umbilical cord blood (UCB) of infants with moderate and severe HIE and has the potential to be developed as a predictive biomarker. Normal reference ranges for IL-16 in UCB have not been previously described. The aim of this study was to determine normative levels of IL-16 in full term neonates using UCB following uncomplicated deliveries and to examine the effect of labour on cord IL-16 values.Design and methods: Full term infants were recruited as part of an ongoing birth cohort study, the Cork BASELINE Birth Cohort Study. All had UCB drawn and bio-banked at - 80 degrees C, within 3 hours of birth. Samples for this experiment were chosen from this population based cohort study to represent uncomplicated pre-labour caesarean sections and spontaneous vaginal deliveries. Analysis was performed on plasma EDTA, using ELISA Quantikine (R) (R;D Systems, Europe).Results: Samples were analysed from 48 infants with two modes of delivery; spontaneous vaginal delivery (n = 12 male, n = 12 female) and elective caesarean section (n = 12 male, n = 12 female). The range of all samples was normally distributed between 87.0 and 114.6 pg/ml. Overall mean (SD) for IL-16 was 102.9 (21.5) pg/ml. Levels were not affected by spontaneous vaginal delivery or gender.Conclusion: For the first time we have described the expected range of cord plasma IL-16 levels in healthy term infants following pre-labour and post-labour delivery. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. - 10.1016/j.clinbiochem.2013.07.012 DA - 2013/12 ER -
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@article{V243940130, = {Denihan, NM and Looney, AM and Boylan, GB and Walsh, BH and Murray, DM }, = {2013}, = {December}, = {Clinical biochemistry}, = {Normative levels of Interleukin 16 in umbilical cord blood}, = {Validated}, = {()}, = {Interleukin 16 Hypoxic-ischaemic encephalopathy Umbilical cord blood Cytokines Vaginal delivery Elective caesarean section Pregnancy ELISA ZEALAND SOCIOECONOMIC INDEX TUMOR-NECROSIS-FACTOR DELIVERY IL-16 EXPRESSION PREECLAMPSIA MONOCYTES MODE}, = {46}, pages = {1857--1859}, = {{Objectives: The need for early and accurate prediction of outcome in hypoxic-ischaemic encephalopathy (HIE) remains critical. We have previously demonstrated that Interleulkin 16 (IL-16) is raised in the umbilical cord blood (UCB) of infants with moderate and severe HIE and has the potential to be developed as a predictive biomarker. Normal reference ranges for IL-16 in UCB have not been previously described. The aim of this study was to determine normative levels of IL-16 in full term neonates using UCB following uncomplicated deliveries and to examine the effect of labour on cord IL-16 values.Design and methods: Full term infants were recruited as part of an ongoing birth cohort study, the Cork BASELINE Birth Cohort Study. All had UCB drawn and bio-banked at - 80 degrees C, within 3 hours of birth. Samples for this experiment were chosen from this population based cohort study to represent uncomplicated pre-labour caesarean sections and spontaneous vaginal deliveries. Analysis was performed on plasma EDTA, using ELISA Quantikine (R) (R;D Systems, Europe).Results: Samples were analysed from 48 infants with two modes of delivery; spontaneous vaginal delivery (n = 12 male, n = 12 female) and elective caesarean section (n = 12 male, n = 12 female). The range of all samples was normally distributed between 87.0 and 114.6 pg/ml. Overall mean (SD) for IL-16 was 102.9 (21.5) pg/ml. Levels were not affected by spontaneous vaginal delivery or gender.Conclusion: For the first time we have described the expected range of cord plasma IL-16 levels in healthy term infants following pre-labour and post-labour delivery. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.}}, = {10.1016/j.clinbiochem.2013.07.012}, source = {IRIS} }
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AUTHORS | Denihan, NM,Looney, AM,Boylan, GB,Walsh, BH,Murray, DM | ||
YEAR | 2013 | ||
MONTH | December | ||
JOURNAL_CODE | Clinical biochemistry | ||
TITLE | Normative levels of Interleukin 16 in umbilical cord blood | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | Interleukin 16 Hypoxic-ischaemic encephalopathy Umbilical cord blood Cytokines Vaginal delivery Elective caesarean section Pregnancy ELISA ZEALAND SOCIOECONOMIC INDEX TUMOR-NECROSIS-FACTOR DELIVERY IL-16 EXPRESSION PREECLAMPSIA MONOCYTES MODE | ||
VOLUME | 46 | ||
ISSUE | |||
START_PAGE | 1857 | ||
END_PAGE | 1859 | ||
ABSTRACT | Objectives: The need for early and accurate prediction of outcome in hypoxic-ischaemic encephalopathy (HIE) remains critical. We have previously demonstrated that Interleulkin 16 (IL-16) is raised in the umbilical cord blood (UCB) of infants with moderate and severe HIE and has the potential to be developed as a predictive biomarker. Normal reference ranges for IL-16 in UCB have not been previously described. The aim of this study was to determine normative levels of IL-16 in full term neonates using UCB following uncomplicated deliveries and to examine the effect of labour on cord IL-16 values.Design and methods: Full term infants were recruited as part of an ongoing birth cohort study, the Cork BASELINE Birth Cohort Study. All had UCB drawn and bio-banked at - 80 degrees C, within 3 hours of birth. Samples for this experiment were chosen from this population based cohort study to represent uncomplicated pre-labour caesarean sections and spontaneous vaginal deliveries. Analysis was performed on plasma EDTA, using ELISA Quantikine (R) (R;D Systems, Europe).Results: Samples were analysed from 48 infants with two modes of delivery; spontaneous vaginal delivery (n = 12 male, n = 12 female) and elective caesarean section (n = 12 male, n = 12 female). The range of all samples was normally distributed between 87.0 and 114.6 pg/ml. Overall mean (SD) for IL-16 was 102.9 (21.5) pg/ml. Levels were not affected by spontaneous vaginal delivery or gender.Conclusion: For the first time we have described the expected range of cord plasma IL-16 levels in healthy term infants following pre-labour and post-labour delivery. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. | ||
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DOI_LINK | 10.1016/j.clinbiochem.2013.07.012 | ||
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