TY  - JOUR
  - Walsh, BH,Boylan, GB,Livingstone, V,Kenny, LC,Dempsey, EM,Murray, DM
  - 2013
  - July
  - Pediatric Critical Care Medicine
  - Cord Blood Proteins and Multichannel-Electroencephalography in Hypoxic-Ischemic Encephalopathy
  - Validated
  - Altmetric: 1 ()
  - asphyxia neonatorum biomarker brain electroencephalography human hypoxia-ischemia infant newborn PERINATAL ASPHYXIA PROGNOSTIC VALUE CEREBROSPINAL-FLUID TERM INFANTS NEONATAL ENCEPHALOPATHY MR SPECTROSCOPY GROWTH-FACTOR APGAR SCORE NEWBORNS EEG
  - 14
  - 621
  - 630
  - Objective: To explore the association between multiple umbilical cord blood proteins and severity of hypoxic-ischemic encephalopathy as defined by continuous multichannel electroencephalography.Design: A prospective case-control cohort study, which was divided into separate exploratory and validation cohorts.Setting: A single tertiary neonatal intensive care facility.Patients: The study recruited full-term infants with perinatal asphyxia and controls. Identical procedures were used to recruit a representative exploratory sample (n = 30) and a subsequent validation cohort (n = 100).Intervention: All had umbilical cord blood drawn and biobanked at delivery, continuous multichannel electroencephalography commenced in the first 24 hours, and a modified Sarnat score assigned. Analysis of 37 potential cord blood protein markers of hypoxic-ischemic encephalopathy was performed using Luminex multiplex assays.Measurements and Results: Cord blood from 130 infants was analyzed. Interleukin-16 and interleukin-6 significantly differentiated between a moderate-severely abnormal and normal-mildly abnormal electroencephalography background in both exploratory (p = 0.005 and p = 0.016, respectively) and validation cohorts (p = 0.039 and p = 0.024, respectively). To develop a predictive model for a moderate-severely abnormal electroencephalography, stepwise regression analysis was used to combine these analytes with current standard clinical markers of asphyxia (pH, base deficit, and 10-min Apgar). Only Apgar score and interleukin-16 remained in the model, which was highly predictive of an abnormal electroencephalography (area under the curve [AUC] = 0.956, p < 0.001, positive predictive value = 89%, and negative predictive value = 94%).Conclusions: Cord blood interleukin-6 and interleukin-16 were associated with electrographic grade of hypoxic-ischemic encephalopathy. To predict an abnormal electroencephalography, interleukin-16 and 10-minute Apgar used in combination performed better than current markers.
  - 10.1097/PCC.0b013e318291793f
DA  - 2013/07
ER  - 

@article{V271355414,
   = {Walsh,  BH and Boylan,  GB and Livingstone,  V and Kenny,  LC and Dempsey,  EM and Murray,  DM },
   = {2013},
   = {July},
   = {Pediatric Critical Care Medicine},
   = {Cord Blood Proteins and Multichannel-Electroencephalography in Hypoxic-Ischemic Encephalopathy},
   = {Validated},
   = {Altmetric: 1 ()},
   = {asphyxia neonatorum biomarker brain electroencephalography human hypoxia-ischemia infant newborn PERINATAL ASPHYXIA PROGNOSTIC VALUE CEREBROSPINAL-FLUID TERM INFANTS NEONATAL ENCEPHALOPATHY MR SPECTROSCOPY GROWTH-FACTOR APGAR SCORE NEWBORNS EEG},
   = {14},
  pages = {621--630},
   = {{Objective: To explore the association between multiple umbilical cord blood proteins and severity of hypoxic-ischemic encephalopathy as defined by continuous multichannel electroencephalography.Design: A prospective case-control cohort study, which was divided into separate exploratory and validation cohorts.Setting: A single tertiary neonatal intensive care facility.Patients: The study recruited full-term infants with perinatal asphyxia and controls. Identical procedures were used to recruit a representative exploratory sample (n = 30) and a subsequent validation cohort (n = 100).Intervention: All had umbilical cord blood drawn and biobanked at delivery, continuous multichannel electroencephalography commenced in the first 24 hours, and a modified Sarnat score assigned. Analysis of 37 potential cord blood protein markers of hypoxic-ischemic encephalopathy was performed using Luminex multiplex assays.Measurements and Results: Cord blood from 130 infants was analyzed. Interleukin-16 and interleukin-6 significantly differentiated between a moderate-severely abnormal and normal-mildly abnormal electroencephalography background in both exploratory (p = 0.005 and p = 0.016, respectively) and validation cohorts (p = 0.039 and p = 0.024, respectively). To develop a predictive model for a moderate-severely abnormal electroencephalography, stepwise regression analysis was used to combine these analytes with current standard clinical markers of asphyxia (pH, base deficit, and 10-min Apgar). Only Apgar score and interleukin-16 remained in the model, which was highly predictive of an abnormal electroencephalography (area under the curve [AUC] = 0.956, p < 0.001, positive predictive value = 89%, and negative predictive value = 94%).Conclusions: Cord blood interleukin-6 and interleukin-16 were associated with electrographic grade of hypoxic-ischemic encephalopathy. To predict an abnormal electroencephalography, interleukin-16 and 10-minute Apgar used in combination performed better than current markers.}},
   = {10.1097/PCC.0b013e318291793f},
  source = {IRIS}
}