| Year | Publication |
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| (2014) | 'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats' O'Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O'Toole PW, Dinan TG, Cryan JF (2014) 'Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats'. Neuroscience, 277C :885-901 [DOI] [Details] |
| (2013) | 'Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse' O'Carroll C, Moloney G, Hurley G, Melgar S, Brint E, Nally K, Nibbs RJ, Shanahan F, Carmody RJ (2013) 'Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse'. Clinical and Experimental Immunology, 173 (2):332-342 [DOI] [Details] |
| (2013) | 'Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages' Regan, T,Nally, K,Carmody, R,Houston, A,Shanahan, F,MacSharry, J,Brint, E (2013) 'Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages'. Journal of immunology (Baltimore, Md. : 1950), 191 :6084-6092 [DOI] [Details] |
| (2013) | 'TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNF alpha, from CD3+CD161+T cells to exacerbate gut inflammation' Jin, S.,Chin, J.,Seeber, S.,Niewoehner, J.,Weiser, B.,Beaucamp, N.,Woods, J.,Murphy, C.,Fanning, A.,Shanahan, F.,Nally, K.,Kajekar, R.,Salas, A.,Planell, N.,Lozano, J.,Panes, J.,Parmar, H.,DeMartino, J.,Narula, S.,Thomas-Karyat, D. A. (2013) 'TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNF alpha, from CD3+CD161+T cells to exacerbate gut inflammation'. Mucosal immunology, 6 (55):886-899 [Details] |
| (2012) | 'Shining a Light on Intestinal Traffic' Murphy, C. T.,Nally, K.,Shanahan, F.,Melgar, S. (2012) 'Shining a Light on Intestinal Traffic'. Clin Dev Immunol, [Details] |
| (2012) | 'Differential intestinal M-cell gene expression response to gut commensals' Lapthorne, S.,MacSharry, J.,Scully, P.,Nally, K.,Shanahan, F. (2012) 'Differential intestinal M-cell gene expression response to gut commensals'. Immunology, 136 (33):312-324312 [Details] |
| (2012) | 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium' Murphy, C. T.,Hall, L. J.,Hurley, G.,Quinlan, A.,MacSharry, J.,Shanahan, F.,Nally, K.,Melgar, S. (2012) 'The Sphingosine-1-Phosphate Analogue FTY720 Impairs Mucosal Immunity and Clearance of the Enteric Pathogen Citrobacter rodentium'. Infect Immun, 80 (88):2712-27232712 [Details] |
| (2012) | 'Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection' Fanning, S.,Hall, L. J.,Cronin, M.,Zomer, A.,MacSharry, J.,Goulding, D.,Motherway, M. O.,Shanahan, F.,Nally, K.,Dougan, G.,van Sinderen, D. (2012) 'Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection'. Proc Natl Acad Sci U S Aproc Natl Acad Sci U S A, 109 (66):2108-2113 [Details] |
| (2012) | 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production' Miyauchi, E.,O'Callaghan, J.,Butto, L. F.,Hurley, G.,Melgar, S.,Tanabe, S.,Shanahan, F.,Nally, K.,O'Toole, P. W. (2012) 'Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: strain dependence and attenuation by bacteriocin production'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 303 (99) [Details] |
| (2011) | 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis' Hall, L. J.,Faivre, E.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2011) 'Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis'. Dig Dis Sci, 56 (11):79-8979 [Details] |
| (2010) | 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis' Murphy, C. T.,Moloney, G.,MacSharry, J.,Haynes, A.,Faivre, E.,Quinlan, A.,McLean, P. G.,Lee, K.,O'Mahony, L.,Shanahan, F.,Melgar, S.,Nally, K. (2010) 'Technical Advance: Function and efficacy of an alpha(4)-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis'. J Leukoc Biol, 88 (66):1271-12781271 [Details] |
| (2010) | 'Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease' Docena, G.,Rovedatti, L.,Kruidenier, L.,Fanning, A.,Leakey, N. A.,Knowles, C. H.,Lee, K.,Shanahan, F.,Nally, K.,McLean, P. G.,Di Sabatino, A.,MacDonald, T. T. (2010) 'Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease'. Clin Exp Immunolclin Exp Immunol, 162 (11):108-115 [Details] |
| (2010) | 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis' Murphy, C. T.,Moloney, G.,Hall, L. J.,Quinlan, A.,Faivre, E.,Casey, P.,Shanahan, F.,Melgar, S.,Nally, K. (2010) 'Use of bioluminescence imaging to track neutrophil migration and its inhibition in experimental colitis'. Clin Exp Immunolclin Exp Immunol, 162 (11):188-196 [Details] |
| (2005) | 'Targeting the Fas/Fas ligand pathway in cancer' O'Brien, D. I.,Nally, K.,Kelly, R. G.,O'Connor, T. M.,Shanahan, F.,O'Connell, J. (2005) 'Targeting the Fas/Fas ligand pathway in cancer'. Expert Opin Ther Targets, 9 (55):1031-10441031 [Details] |
| (2002) | 'Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine' Kelly, R. G.,Nally, K.,Shanahan, F.,O'Connell, J. (2002) 'Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine'. Cell Signaling, Transcription, and Translation as Therapeutic Targets, 973 :555-558555 [Details] |
| (2000) | 'Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis' O'connell, J.,Bennett, M. W.,Nally, K.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. (2000) 'Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis'. Journal Of Cellular Physiology, 185 (33):331-338 [Details] |
| (2000) | 'Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict' O'connell, J.,Bennett, M. W.,Nally, K.,Houston, A.,O'Sullivan, G. C.,Shanahan, F. (2000) 'Altered mechanisms of apoptosis in colon cancer: Fas resistance and counterattack in the tumor-immune conflict'. Colorectal Cancer: New Aspects Of Molecular Biology And Immunology And Their Clinical Applicationscolorectal Cancer: New Aspects Of Molecular Biology And Immunology And Their Clinical Applications, 910 :178-195 [Details] |
| Year | Publication |
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| (2014) | DDW, Chicago 2014 Darby T, Smith E, Quinlan A, Hurley G, Clarke D, Shanahan F, Nally K, Melgar S. (2014) The colonic adherent-invasive Escherichia coli strain HM605 induces anti-apoptotic responses in intestinal epithelial cells, reduces barrier integrity and worsens experimental colitis DDW, Chicago 2014 [Details] |
| (2012) | National Conference 2012 Kennedy, B.,Kennedy, M. P.,Plant, B. J.,Henry, M. T.,O'Driscoll, M.,Maher, M.,Nally, K.,Shanahan, F.,Curran, D. R.,O'Connor, T. M. (2012) Bone Marrow and Peripheral Blood Derived CD14(+) Cells as Agents of Tissue Remodelling in Idiopathic Pulmonary Fibrosis National Conference 2012 [Details] |
| (2012) | DDW 2012; Gastroenterology Hall, L. J.,Murphy, C.,Quinlan, A.,Hurley, G.,Shanahan, F.,Nally, K.,Melgar, S. (2012) NK Cells Protect Mice During Acute Experimental Colitis by Regulating Neutrophil Function via NKG2A-dependent Mechanisms DDW 2012; Gastroenterology [Details] |
| (2012) | DDW 2012; Gastroenterology Darby, T.,Clarke, D.,Nally, K.,Shanahan, F.,Melgar, S. (2012) Deficiency in ATG16L1 Increases the Ability of the Adherent-Invasive Escherichia coli (HM605) to Replicate in and Reduce Barrier Integrity of Intestinal Epithelial Cells DDW 2012; Gastroenterology [Details] |
| (2012) | DDW 2012; Gastroenterology Ambrose, M.,Moloney, G.,Heuston, S.,Rahman, A.,Davies, J. M.,Murphy, C.,Hurley, G.,Quinlan, A.,Karras, J.,Hessel, E. M.,Prinjha, R.,Lee, K.,Hyland, N. P.,Shanahan, F.,Hammarstrom, M. L.,Melgar, S.,Nally, K. (2012) MiR-375 is a Key Regulator of Intestinal Homeostasis in Response to Inflammatory Stress DDW 2012; Gastroenterology [Details] |
| (2012) | DDW 2012; Gastroenterology Fanning, A.,Moloney, G.,MacSharry, J.,Ambrose, M.,Quigley, E. M.,Shanahan, F.,Melgar, S.,Nally, K. (2012) Elevated Expression of the Cytosolic DNA Sensors AIM2 and ZBP1/DAI in Active Ulcerative Colitis but Not Crohn's Disease Colonic Tissue DDW 2012; Gastroenterology [Details] |
| (2012) | DDW 2012; Gastroenterology Moloney, G.,Fanning, A.,Mac Sharry, J.,Hall, L. J.,Shanahan, F.,Quigley, E. M.,Melgar, S.,Nally, K. (2012) Altered Expression and Activation of the CXCR3/CXCL10 Chemokine System in Irritable Bowel Syndrome (IBS) Mucosal Biopsy Tissue DDW 2012; Gastroenterology [Details] |
| (2012) | DDW 2012; Gastroenterology Beltran, C.,Fanning, A.,Moloney, G.,Grenham, S.,Heuston, S.,Melgar, S.,Nally, K.,Cryan, J. F.,Dinan, T. G.,Quigley, E. M. (2012) The Role of IL-9/Il9r in Irritable Bowel Syndrome DDW 2012; Gastroenterology [Details] |
| (2012) | DDW 2012; Gastroenterology Fanning, A.,Moloney, G.,MacSharry, J.,Ambrose, M.,Prinjha, R.,Lee, K.,Quigley, E. M.,Shanahan, F.,Melgar, S.,Nally, K. (2012) Differential Expression of Epigenetic Modifier Genes in Inflammatory Bowel Disease Colonic Tissue-PRDM1 and PRDM8 are up-Regulated in Active Ulcerative Colitis DDW 2012; Gastroenterology [Details] |
| (2011) | DDW 2011; Gastroenterology Moloney, G.,Fanning, A.,O'Malley, D.,Scanlan, N.,Cryan, J. F.,Dinan, T. G.,Shanahan, F.,Quigley, E. M.,Melgar, S.,Nally, K. (2011) Stimulation of T-Cells in Irritable Bowel Syndrome (IBS) Mucosal Biopsy Tissue Releases Cytokines Which Selectively Activate Submucosal Neurons DDW 2011; Gastroenterology [Details] |
| (2011) | DDW 2011; Gastroenterology Lapthorne, S.,MacSharry, J.,Scully, P.,Nally, K.,Shanahan, F. (2011) The Discriminatory Intelligence of M Cells - Beyond a Simple Translocation Portal DDW 2011; Gastroenterology [Details] |
| (2011) | DDW 2011; Gastroenterology Murphy, C.,Hall, L. J.,Hurley, G.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2011) The Immunomodulatory Drug FTY720 Prevents Clearance of Citrobacter rodentium Infection in Mice DDW 2011; Gastroenterology [Details] |
| (2011) | DDW 2011; Gastroenterology Woznicki, J.,Shanahan, F.,Melgar, S.,Nally, K. (2011) IFN-gamma and TNF-alpha Synergise to Induce Expression of the Novel PRO-Apoptotic Gene BCL-G and Apoptosis in Intestinal Epithelial Cells and BCL-G Expression is Reduced in Inflammatory Bowel Disease (IBD) and Colon Cancer DDW 2011; Gastroenterology [Details] |
| (2011) | DDW 2011; Gastroenterology Ambrose, M.,O'Keeffe, A.,Fanning, A.,Murphy, C.,Hurley, G.,Quinlan, A.,Mac Sharry, J.,Hammarstrom, M. L.,Hessel, E. M.,Lee, K.,Shanahan, F.,Melgar, S.,Nally, K. (2011) MiR-146a Negatively Regulates IL-17A Inflammatory Response and is Elevated in Intestinal Epithelial Cells From Inflammatory Bowel Disease (IBD) Patients DDW 2011; Gastroenterology [Details] |
| (2009) | DDW 2009; Gastroenterology Moloney, G.,Corr, S.,Hall, L. J.,Murphy, C.,Quinlan, A.,Kruidenier, L.,Calver, A. R.,Mclean, P. G.,Lee, K.,Shanahan, F.,Nally, K.,Melgar, S. (2009) The Effect of the Farnesoid X Receptor (FXR) and It's Agonist-GSK488062B-On Experimental Models of Colitis and Cytokine Production from IBD Tissue DDW 2009; Gastroenterology [Details] |
| (2009) | DDW 2009; Gastroenterology Hall, L. J.,Quinlan, A.,Shanahan, F.,Nally, K.,Melgar, S. (2009) Natural Killer Cell Responses in Both Acute and Chronic Phases of a Murine Model of Experimental Colitis DDW 2009; Gastroenterology [Details] |
| (2008) | DDW 2008; Gastroenterology Corr, S. C.,O'Hara, A.,O'Mahony, L.,Nally, K.,Shanahan, F.,Hill, C.,Gahan, C. G. (2008) Mechanism of epithelial CCL20 response to listeria DDW 2008; Gastroenterology [Details] |
| (2008) | DDW 2008; Gastroenterology Docena, G. H.,Fanning, A.,Rovedatti, L.,Di Sabatino, A.,Leakey, N. A.,Knowles, C. H.,Lee, K.,Shanahan, F.,Nally, K.,McLean, P.,MacDonald, T. T.,Kruidenier, L. (2008) Activation and modulation of the MAP kinase pathway in IBD DDW 2008; Gastroenterology [Details] |
| (2008) | BMC Gastroenterology Murphy, C.,Moloney, G.,Casey, P.,Haynes, A. C.,Kruidenier, L.,Calver, A.,McLean, P.,Lee, K.,Hill, C.,O'Mahony, L.,Shanahan, F.,Nally, K. (2008) Modification of lymphocyte trafficking in an in vivo model of IBD following administration of a novel alpha 4 integrin antagonist BMC Gastroenterology [Details] |
| (2006) | DDW 2006; Gastroenterology Nally, K.,O'Brien, D.,MacSharry, J.,Bairead, E.,O'Sullivan, G. C.,O'Connell, J.,Shanahan, F. (2006) IFN gamma and TNF alpha synergize to induce maximal NF-kappa B activation, NF-kappa B mediated trail expression and apoptosis of colonic epithelial cells DDW 2006; Gastroenterology [Details] |
| (2004) | DDW 2004; Gastroenterology Nally, K.,O'Brien, D.,O'Connell, J.,Shanahan, F. (2004) Interferon gamma(IFN-gamma) selectively suppresses TNF-alpha-induced COX-1 and COX-2 expression in intestinal epithelial cells by inhibiting NF-kappa B function DDW 2004; Gastroenterology [Details] |
| (2004) | DDW 2004; Gastroenterology Rosberg-Cody, E.,Ross, P.,Nally, K.,Anwar, M.,O'Mahony, L.,Ryan, A.,Hussey, S.,Murphy, B.,Fitzgerald, G.,Shanahan, F.,Stanton, C. (2004) Metabolic basis of host-flora interactions in the gut - Role of CLA DDW 2004; Gastroenterology [Details] |
| (2001) | DDW 2001; Gastroenterology Nally, K.,O'Connell, J.,Morgan, J.,Collins, J. K.,O'Sullivan, G. C.,Shanahan, F. (2001) IGF-1 protects colonic epithelial cells from cytokine induced apoptosis by maintaining cellular phospho-tyrosine content and preventing cytochrome C release DDW 2001; Gastroenterology [Details] |
| (2001) | DDW 2001; Gastroenterology Nally, K.,Mullan, B.,O'Connell, J.,Morgan, J.,Collins, J. K.,O'Sullivan, G. C.,Shanahan, F. (2001) Pro inflammatory cytokines suppress p53 function in colonic epithelial cells - A link between inflammation and tumorigenesis DDW 2001; Gastroenterology [Details] |
| (2001) | DDW 2001; Gastroenterology Nally, K.,Kelly, R.,Ryan, P.,O'Connell, J.,O'Sullivan, G. C.,Morgan, J.,Shanahan, F. (2001) The chemopreventative agent N-acetyl-L-cysteine (NAC) decreases epidermal growth factor receptor (EGFR) levels on colonic carcinoma cell lines DDW 2001; Gastroenterology [Details] |
| (2000) | DDW 2000; Gastroenterology Nally, K.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. L. (2000) Maximal activation of epithelial NFKB - An additional molecular mechanism underlying synergy between IFN-Gamma and TNF-Alpha DDW 2000; Gastroenterology [Details] |
| (2000) | DDW 2000; Gastroenterology Nally, K.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shannon, F. L. (2000) The Th1 cytokines IFN-gamma and TNF-alpha reactivate components of the p53 pathway in mutant p53 epithelial cells DDW 2000; Gastroenterology [Details] |
| (1999) | DDW 1999; Gastroenterology Nally, K.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. L. J. (1999) The commitment to die: Role of c-myc in lowering epithelial cell threshold for apoptosis by IFN-gamma and TNF-alpha DDW 1999; Gastroenterology [Details] |
| (1998) | DDW 1998; Gastroenterology Nally, K.,Newton, F.,O'Connell, J.,Morgan, J.,O'Sullivan, G. C.,Collins, J. K.,Shanahan, F. (1998) Epithelial cytoprotection is part of the therapeutic effect of interleukin-10 in mucosal inflammation DDW 1998; Gastroenterology [Details] |
| (1997) | DDW 1997; Gastroenterology Winter, D. C.,Nally, K.,OCallaghan, J.,Matthews, J. B.,Harvey, B. J.,OSullivan, G. C.,Shanahan, F. (1997) Cytoskeletal disruption by jasplakinolide inhibits colon cancer growth in vitro DDW 1997; Gastroenterology [Details] |