IRIS publication 160960640
Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine
RIS format for Endnote and similar
TY - - Other - Kelly, RG,Nally, K,Shanahan, F,O'Connell, J - 2002 - February - Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine - Validated - 1 - () - type I insulin-like growth factor receptor (IGF-IR) N-acetyl-L-cysteine (NAC) colon epithelial cells ACETYLCYSTEINE INHIBITION - Increased expression of the type I insulin-like growth factor receptor (IGF-IR) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-IR on three colorectal adenocarcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC. - 555 - 558 DA - 2002/02 ER -
BIBTeX format for JabRef and similar
@misc{V160960640, = {Other}, = {Kelly, RG and Nally, K and Shanahan, F and O'Connell, J }, = {2002}, = {February}, = {Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine}, = {Validated}, = {1}, = {()}, = {type I insulin-like growth factor receptor (IGF-IR) N-acetyl-L-cysteine (NAC) colon epithelial cells ACETYLCYSTEINE INHIBITION}, = {{Increased expression of the type I insulin-like growth factor receptor (IGF-IR) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-IR on three colorectal adenocarcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC.}}, pages = {555--558}, source = {IRIS} }
Data as stored in IRIS
OTHER_PUB_TYPE | Other | ||
AUTHORS | Kelly, RG,Nally, K,Shanahan, F,O'Connell, J | ||
YEAR | 2002 | ||
MONTH | February | ||
TITLE | Type I insulin-like growth factor receptor expression on colorectal adenocarcinoma cell lines is decreased in response to the chemopreventive agent N-acetyl-L-cysteine | ||
RESEARCHER_ROLE | |||
STATUS | Validated | ||
PEER_REVIEW | 1 | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | type I insulin-like growth factor receptor (IGF-IR) N-acetyl-L-cysteine (NAC) colon epithelial cells ACETYLCYSTEINE INHIBITION | ||
REFERENCE | |||
ABSTRACT | Increased expression of the type I insulin-like growth factor receptor (IGF-IR) is associated with colon cancer, while the antioxidant N-acetyl-L-cysteine (NAC) is known to suppress colonic proliferation. We demonstrate that NAC down-regulates the expression of IGF-IR on three colorectal adenocarcinoma cell lines (HT29, SW480, and LoVo). NAC also abrogates the proliferative effect of IGF-I on HT29 cells. This indicates a novel mechanism for the therapeutic effects of NAC. | ||
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START_PAGE | 555 | ||
END_PAGE | 558 | ||
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