IRIS publication 274158566
Bioconjugated iron oxide nanocubes: synthesis, functionalization, and vectorization
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TY - JOUR - Wortmann, L.; Ilyas, S.; Niznansky, D.; Valldor, M.; Arroub, K.; Berger, N.; Rahme, K.; Holmes, J.; Mathur, S. - 2014 - October - Acs Applied Materials ; Interfaces - Bioconjugated iron oxide nanocubes: synthesis, functionalization, and vectorization - Published - Altmetric: 1 () - 6 - 19 - 16631 - 16642 - A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (8−40 nm) and enabled biovectorization of SiO2@Fe3O4 core−shell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV−vis, ζ- potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging. - Washington, DC, USA - http://pubs.acs.org/journal/aamick - 10.1021/am503068r DA - 2014/10 ER -
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@article{V274158566, = {Wortmann, L. and Ilyas, S. and Niznansky, D. and Valldor, M. and Arroub, K. and Berger, N. and Rahme, K. and Holmes, J. and Mathur, S.}, = {2014}, = {October}, = {Acs Applied Materials ; Interfaces}, = {Bioconjugated iron oxide nanocubes: synthesis, functionalization, and vectorization}, = {Published}, = {Altmetric: 1 ()}, = {6}, = {19}, pages = {16631--16642}, = {{A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (8−40 nm) and enabled biovectorization of SiO2@Fe3O4 core−shell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV−vis, ζ- potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.}}, = {Washington, DC, USA}, = {http://pubs.acs.org/journal/aamick}, = {10.1021/am503068r}, source = {IRIS} }
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AUTHORS | Wortmann, L.; Ilyas, S.; Niznansky, D.; Valldor, M.; Arroub, K.; Berger, N.; Rahme, K.; Holmes, J.; Mathur, S. | ||
YEAR | 2014 | ||
MONTH | October | ||
JOURNAL_CODE | Acs Applied Materials ; Interfaces | ||
TITLE | Bioconjugated iron oxide nanocubes: synthesis, functionalization, and vectorization | ||
STATUS | Published | ||
TIMES_CITED | Altmetric: 1 () | ||
SEARCH_KEYWORD | |||
VOLUME | 6 | ||
ISSUE | 19 | ||
START_PAGE | 16631 | ||
END_PAGE | 16642 | ||
ABSTRACT | A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (8−40 nm) and enabled biovectorization of SiO2@Fe3O4 core−shell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV−vis, ζ- potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging. | ||
PUBLISHER_LOCATION | Washington, DC, USA | ||
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URL | http://pubs.acs.org/journal/aamick | ||
DOI_LINK | 10.1021/am503068r | ||
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