TY  - JOUR
  - Corr SC, Gahan CC, Hill C
  - 2008
  - January
  - Fems Immunology and Medical Microbiology
  - M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis.
  - Validated
  - ()
  - 52
  - 1
  - 2
  - 12
  - M-cells are specialized cells found in the follicle-associated epithelium of intestinal Peyer's patches of gut-associated lymphoid tissue and in isolated lymphoid follicles, appendix and in mucosal-associated lymphoid tissue sites outside the gastrointestinal tract. In the gastrointestinal tract, M-cells play an important role in transport of antigen from the lumen of the small intestine to mucosal lymphoid tissues, where processing and initiation of immune responses occur. Thus, M-cells act as gateways to the mucosal immune system and this function has been exploited by many invading pathogens. Understanding the mechanism by which M-cells sample antigen will inform the design of oral vaccines with improved efficacy in priming mucosal and systemic immune responses. In this review, the origin and morphology of M-cells, and their role in mucosal immunity and pathogenesis of infections are discussed.
  - 10.1111/j.1574-695X.2007.00359.x
DA  - 2008/01
ER  - 

@article{V14901176,
   = {Corr SC,  Gahan CC and  Hill C },
   = {2008},
   = {January},
   = {Fems Immunology and Medical Microbiology},
   = {M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis.},
   = {Validated},
   = {()},
   = {52},
   = {1},
  pages = {2--12},
   = {{M-cells are specialized cells found in the follicle-associated epithelium of intestinal Peyer's patches of gut-associated lymphoid tissue and in isolated lymphoid follicles, appendix and in mucosal-associated lymphoid tissue sites outside the gastrointestinal tract. In the gastrointestinal tract, M-cells play an important role in transport of antigen from the lumen of the small intestine to mucosal lymphoid tissues, where processing and initiation of immune responses occur. Thus, M-cells act as gateways to the mucosal immune system and this function has been exploited by many invading pathogens. Understanding the mechanism by which M-cells sample antigen will inform the design of oral vaccines with improved efficacy in priming mucosal and systemic immune responses. In this review, the origin and morphology of M-cells, and their role in mucosal immunity and pathogenesis of infections are discussed.}},
   = {10.1111/j.1574-695X.2007.00359.x},
  source = {IRIS}
}