IRIS publication 243942080
Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging
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TY - JOUR - Turroni, F,Bottacini, F,Foroni, E,Mulder, I,Kim, JH,Zomer, A,Sanchez, B,Bidossi, A,Ferrarini, A,Giubellini, V,Delledonne, M,Henrissat, B,Coutinho, P,Oggioni, M,Fitzgerald, GF,Mills, D,Margolles, A,Kelly, D,van Sinderen, D,Ventura, M - 2010 - November - Proceedings of The National Academy of Sciences of The United States of America - Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging - Validated - WOS: 269 () - coevolution genomics host-glycans metabolism human gut intestinal bacteria mucin ALPHA-N-ACETYLGALACTOSAMINIDASE HUMAN-MILK OLIGOSACCHARIDES GLYCOSIDE HYDROLASE FAMILY HUMAN INTESTINAL-TRACT HUMAN DISTAL GUT AKKERMANSIA-MUCINIPHILA MUCIN GLYCOPROTEINS MOLECULAR-CLONING LONGUM BACTERIAL - 107 - 19514 - 19519 - The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology. - 10.1073/pnas.1011100107 DA - 2010/11 ER -
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@article{V243942080, = {Turroni, F and Bottacini, F and Foroni, E and Mulder, I and Kim, JH and Zomer, A and Sanchez, B and Bidossi, A and Ferrarini, A and Giubellini, V and Delledonne, M and Henrissat, B and Coutinho, P and Oggioni, M and Fitzgerald, GF and Mills, D and Margolles, A and Kelly, D and van Sinderen, D and Ventura, M }, = {2010}, = {November}, = {Proceedings of The National Academy of Sciences of The United States of America}, = {Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging}, = {Validated}, = {WOS: 269 ()}, = {coevolution genomics host-glycans metabolism human gut intestinal bacteria mucin ALPHA-N-ACETYLGALACTOSAMINIDASE HUMAN-MILK OLIGOSACCHARIDES GLYCOSIDE HYDROLASE FAMILY HUMAN INTESTINAL-TRACT HUMAN DISTAL GUT AKKERMANSIA-MUCINIPHILA MUCIN GLYCOPROTEINS MOLECULAR-CLONING LONGUM BACTERIAL}, = {107}, pages = {19514--19519}, = {{The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology.}}, = {10.1073/pnas.1011100107}, source = {IRIS} }
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AUTHORS | Turroni, F,Bottacini, F,Foroni, E,Mulder, I,Kim, JH,Zomer, A,Sanchez, B,Bidossi, A,Ferrarini, A,Giubellini, V,Delledonne, M,Henrissat, B,Coutinho, P,Oggioni, M,Fitzgerald, GF,Mills, D,Margolles, A,Kelly, D,van Sinderen, D,Ventura, M | ||
YEAR | 2010 | ||
MONTH | November | ||
JOURNAL_CODE | Proceedings of The National Academy of Sciences of The United States of America | ||
TITLE | Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging | ||
STATUS | Validated | ||
TIMES_CITED | WOS: 269 () | ||
SEARCH_KEYWORD | coevolution genomics host-glycans metabolism human gut intestinal bacteria mucin ALPHA-N-ACETYLGALACTOSAMINIDASE HUMAN-MILK OLIGOSACCHARIDES GLYCOSIDE HYDROLASE FAMILY HUMAN INTESTINAL-TRACT HUMAN DISTAL GUT AKKERMANSIA-MUCINIPHILA MUCIN GLYCOPROTEINS MOLECULAR-CLONING LONGUM BACTERIAL | ||
VOLUME | 107 | ||
ISSUE | |||
START_PAGE | 19514 | ||
END_PAGE | 19519 | ||
ABSTRACT | The human intestine is densely populated by a microbial consortium whose metabolic activities are influenced by, among others, bifidobacteria. However, the genetic basis of adaptation of bifidobacteria to the human gut is poorly understood. Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin. Proteome and transcriptome profiling revealed a set of chromosomal loci responsible for mucin metabolism that appear to be under common transcriptional control and with predicted functions that allow degradation of various O-linked glycans in mucin. Conservation of the latter gene clusters in various B. bifidum strains supports the notion that host-derived glycan catabolism is an important colonization factor for B. bifidum with concomitant impact on intestinal microbiota ecology. | ||
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DOI_LINK | 10.1073/pnas.1011100107 | ||
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