TY  - JOUR
  - Egan, M,Motherway, MO,Ventura, M,van Sinderen, D
  - 2014
  - July
  - Applied and Environmental Microbiology
  - Metabolism of Sialic Acid by Bifidobacterium breve UCC2003
  - Validated
  - Altmetric: 2 ()
  - N-ACETYLNEURAMINATE LYASE HUMAN-MILK OLIGOSACCHARIDES DNA-MICROARRAY DATA ESCHERICHIA-COLI LACTOCOCCUS-LACTIS GENE-EXPRESSION HAEMOPHILUS-INFLUENZAE CLOSTRIDIUM-PERFRINGENS GENOME SEQUENCE INFANT FORMULAS
  - 80
  - 4414
  - 4426
  - Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin-and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010.
  - 10.1128/AEM.01114-14
DA  - 2014/07
ER  - 

@article{V271355911,
   = {Egan,  M and Motherway,  MO and Ventura,  M and van Sinderen,  D },
   = {2014},
   = {July},
   = {Applied and Environmental Microbiology},
   = {Metabolism of Sialic Acid by Bifidobacterium breve UCC2003},
   = {Validated},
   = {Altmetric: 2 ()},
   = {N-ACETYLNEURAMINATE LYASE HUMAN-MILK OLIGOSACCHARIDES DNA-MICROARRAY DATA ESCHERICHIA-COLI LACTOCOCCUS-LACTIS GENE-EXPRESSION HAEMOPHILUS-INFLUENZAE CLOSTRIDIUM-PERFRINGENS GENOME SEQUENCE INFANT FORMULAS},
   = {80},
  pages = {4414--4426},
   = {{Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin-and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010.}},
   = {10.1128/AEM.01114-14},
  source = {IRIS}
}