IRIS publication 271355449
Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design
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TY - JOUR - Santoro, A,Pini, E,Scurti, M,Palmas, G,Berendsen, A,Brzozowska, A,Pietruszka, B,Szczecinska, A,Cano, N,Meunier, N,de Groot, CPGM,Feskens, E,Fairweather-Tait, S,Salvioli, S,Capri, M,Brigidi, P,Franceschi, C,Fabbri, C,Bertarelli, C,Izzi, M,Mazzocchi, M,Chardigny, JM,Morio, B,Rossi, D,Notarfonso, M,O'Toole, PW,Cashman, K,Carding, SR,Nicoletti, C,Jacobs, D,Xipsiti, M,Fernandez, L,Wills, J,Irz, X,Kuosmanen, N,Gonos, ES,Voutetakis, K,Salmon, M,Toussaint, O,Traill, BW,Nocella, G,Caracciolo, B,Xu, WL,Ikonen, M,Tuure, T,Brummer, R,Kadi, F,Breton, S,Triomphe, M,Magario, G,Villani, F,Pancrazio, A,Teufner, B,Stocker, J,Echevarria, FJ,Iglesias, JR,Smrz, F,Krejcirova, L,Koytsomitropoulou, E,Georgakidis, K,Yornuk, R,Ucar, C,Van Ommen, B,Bouwman, J,Collino, S,Jankovics, C,Loso, A,de Vos, W,Fuentes, S,Com - 2014 - March - Mechanisms Of Ageing And Development - Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design - Validated - Altmetric: 8 () - Inflammaging Ageing Mediterranean diet Elderly-tailored foods Gut microbiota CD8(+) T-CELLS STYLE DIET CELLULAR SENESCENCE SYSTEMS BIOLOGY OLDER-ADULTS LONGEVITY IMMUNOSENESCENCE PHENOTYPE DECLINE FRAILTY - 136 - 3 - 13 - The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food ; Drink Industries. (C) 2013 Published by Elsevier Ireland Ltd. - 10.1016/j.mad.2013.12.001 DA - 2014/03 ER -
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@article{V271355449, = {Santoro, A and Pini, E and Scurti, M and Palmas, G and Berendsen, A and Brzozowska, A and Pietruszka, B and Szczecinska, A and Cano, N and Meunier, N and de Groot, CPGM and Feskens, E and Fairweather-Tait, S and Salvioli, S and Capri, M and Brigidi, P and Franceschi, C and Fabbri, C and Bertarelli, C and Izzi, M and Mazzocchi, M and Chardigny, JM and Morio, B and Rossi, D and Notarfonso, M and O'Toole, PW and Cashman, K and Carding, SR and Nicoletti, C and Jacobs, D and Xipsiti, M and Fernandez, L and Wills, J and Irz, X and Kuosmanen, N and Gonos, ES and Voutetakis, K and Salmon, M and Toussaint, O and Traill, BW and Nocella, G and Caracciolo, B and Xu, WL and Ikonen, M and Tuure, T and Brummer, R and Kadi, F and Breton, S and Triomphe, M and Magario, G and Villani, F and Pancrazio, A and Teufner, B and Stocker, J and Echevarria, FJ and Iglesias, JR and Smrz, F and Krejcirova, L and Koytsomitropoulou, E and Georgakidis, K and Yornuk, R and Ucar, C and Van Ommen, B and Bouwman, J and Collino, S and Jankovics, C and Loso, A and de Vos, W and Fuentes, S and Com }, = {2014}, = {March}, = {Mechanisms Of Ageing And Development}, = {Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design}, = {Validated}, = {Altmetric: 8 ()}, = {Inflammaging Ageing Mediterranean diet Elderly-tailored foods Gut microbiota CD8(+) T-CELLS STYLE DIET CELLULAR SENESCENCE SYSTEMS BIOLOGY OLDER-ADULTS LONGEVITY IMMUNOSENESCENCE PHENOTYPE DECLINE FRAILTY}, = {136}, pages = {3--13}, = {{The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food ; Drink Industries. (C) 2013 Published by Elsevier Ireland Ltd.}}, = {10.1016/j.mad.2013.12.001}, source = {IRIS} }
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AUTHORS | Santoro, A,Pini, E,Scurti, M,Palmas, G,Berendsen, A,Brzozowska, A,Pietruszka, B,Szczecinska, A,Cano, N,Meunier, N,de Groot, CPGM,Feskens, E,Fairweather-Tait, S,Salvioli, S,Capri, M,Brigidi, P,Franceschi, C,Fabbri, C,Bertarelli, C,Izzi, M,Mazzocchi, M,Chardigny, JM,Morio, B,Rossi, D,Notarfonso, M,O'Toole, PW,Cashman, K,Carding, SR,Nicoletti, C,Jacobs, D,Xipsiti, M,Fernandez, L,Wills, J,Irz, X,Kuosmanen, N,Gonos, ES,Voutetakis, K,Salmon, M,Toussaint, O,Traill, BW,Nocella, G,Caracciolo, B,Xu, WL,Ikonen, M,Tuure, T,Brummer, R,Kadi, F,Breton, S,Triomphe, M,Magario, G,Villani, F,Pancrazio, A,Teufner, B,Stocker, J,Echevarria, FJ,Iglesias, JR,Smrz, F,Krejcirova, L,Koytsomitropoulou, E,Georgakidis, K,Yornuk, R,Ucar, C,Van Ommen, B,Bouwman, J,Collino, S,Jankovics, C,Loso, A,de Vos, W,Fuentes, S,Com | ||
YEAR | 2014 | ||
MONTH | March | ||
JOURNAL_CODE | Mechanisms Of Ageing And Development | ||
TITLE | Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design | ||
STATUS | Validated | ||
TIMES_CITED | Altmetric: 8 () | ||
SEARCH_KEYWORD | Inflammaging Ageing Mediterranean diet Elderly-tailored foods Gut microbiota CD8(+) T-CELLS STYLE DIET CELLULAR SENESCENCE SYSTEMS BIOLOGY OLDER-ADULTS LONGEVITY IMMUNOSENESCENCE PHENOTYPE DECLINE FRAILTY | ||
VOLUME | 136 | ||
ISSUE | |||
START_PAGE | 3 | ||
END_PAGE | 13 | ||
ABSTRACT | The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food ; Drink Industries. (C) 2013 Published by Elsevier Ireland Ltd. | ||
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DOI_LINK | 10.1016/j.mad.2013.12.001 | ||
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