TY  - JOUR
  - Ryan, KA, Daly, P, Li, Y, Hooton, C, O'Toole, PW
  - 2008
  - April
  - Journal of Antimicrobial Chemotherapy
  - Strain-Specific Inhibition of Helicobacter Pylori By Lactobacillus Salivarius and Other Lactobacilli
  - Validated
  - ()
  - 61
  - 4
  - 831
  - 834
  - Objectives: To investigate the anti-Helicobacter pylori activity of 28 strains of Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites and from different geographical regions.. Methods: An in vitro agar plate diffusion assay was employed to assess the Lactobacillus anti-H. pylori activity.. Results: Nine out of 28 L. salivarius strains and 3/12 other Lactobacillus species tested inhibited H. pylori growth. There was no correlation between ecological niche/geographical location of isolation of the lactobacilli and their inhibitory capability. Further studies on strain L. salivarius UCC119 showed that this strain could inhibit growth of 6/6 clinical isolates of H. pylori, five of which were antibiotic-resistant. This inhibition was not due to acid production and was not mediated by a protein, but did require the presence of live cells.. Conclusions: Growth inhibition of H. pylori by L. salivarius is strain-dependent and is not linked to any particular environmental niche or geographic location. Strains of L. salivarius showing highest anti-H. pylori activity may be useful as an adjunct in the treatment of strains that are resistant to conventional antibiotics..
  - DOI 10.1093/jac/dkn040
DA  - 2008/04
ER  - 

@article{V724321,
   = {Ryan,  KA and  Daly,  P and  Li,  Y and  Hooton,  C and  O'Toole,  PW },
   = {2008},
   = {April},
   = {Journal of Antimicrobial Chemotherapy},
   = {Strain-Specific Inhibition of Helicobacter Pylori By Lactobacillus Salivarius and Other Lactobacilli},
   = {Validated},
   = {()},
   = {61},
   = {4},
  pages = {831--834},
   = {{Objectives: To investigate the anti-Helicobacter pylori activity of 28 strains of Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites and from different geographical regions.. Methods: An in vitro agar plate diffusion assay was employed to assess the Lactobacillus anti-H. pylori activity.. Results: Nine out of 28 L. salivarius strains and 3/12 other Lactobacillus species tested inhibited H. pylori growth. There was no correlation between ecological niche/geographical location of isolation of the lactobacilli and their inhibitory capability. Further studies on strain L. salivarius UCC119 showed that this strain could inhibit growth of 6/6 clinical isolates of H. pylori, five of which were antibiotic-resistant. This inhibition was not due to acid production and was not mediated by a protein, but did require the presence of live cells.. Conclusions: Growth inhibition of H. pylori by L. salivarius is strain-dependent and is not linked to any particular environmental niche or geographic location. Strains of L. salivarius showing highest anti-H. pylori activity may be useful as an adjunct in the treatment of strains that are resistant to conventional antibiotics..}},
   = {DOI 10.1093/jac/dkn040},
  source = {IRIS}
}