IRIS publication 160743638
The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.
RIS format for Endnote and similar
TY - JOUR - Eccles KS, Deasy RE, Fábián L, Maguire AR, Lawrence SE - 2011 - February - The Journal of Organic Chemistry - The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation. - Validated - () - 76 - 4 - 1159 - 1162 - Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals. - 10.1021/jo102148p DA - 2011/02 ER -
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@article{V160743638, = {Eccles KS, Deasy RE and Fábián L, Maguire AR and Lawrence SE }, = {2011}, = {February}, = {The Journal of Organic Chemistry}, = {The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.}, = {Validated}, = {()}, = {76}, = {4}, pages = {1159--1162}, = {{Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.}}, = {10.1021/jo102148p}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Eccles KS, Deasy RE, Fábián L, Maguire AR, Lawrence SE | ||
YEAR | 2011 | ||
MONTH | February | ||
JOURNAL_CODE | The Journal of Organic Chemistry | ||
TITLE | The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation. | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
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VOLUME | 76 | ||
ISSUE | 4 | ||
START_PAGE | 1159 | ||
END_PAGE | 1162 | ||
ABSTRACT | Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals. | ||
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DOI_LINK | 10.1021/jo102148p | ||
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