The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.

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TY  - JOUR
  - Eccles KS, Deasy RE, Fábián L, Maguire AR, Lawrence SE
  - 2011
  - February
  - The Journal of Organic Chemistry
  - The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.
  - Validated
  - ()
  - 76
  - 4
  - 1159
  - 1162
  - Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
  - 10.1021/jo102148p
DA  - 2011/02
ER  - 
@article{V160743638,
   = {Eccles KS,  Deasy RE and  Fábián L,  Maguire AR and  Lawrence SE },
   = {2011},
   = {February},
   = {The Journal of Organic Chemistry},
   = {The use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.},
   = {Validated},
   = {()},
   = {76},
   = {4},
  pages = {1159--1162},
   = {{Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.}},
   = {10.1021/jo102148p},
  source = {IRIS}
}
AUTHORSEccles KS, Deasy RE, Fábián L, Maguire AR, Lawrence SE
YEAR2011
MONTHFebruary
JOURNAL_CODEThe Journal of Organic Chemistry
TITLEThe use of co-crystals for the determination of absolute stereochemistry: an alternative to salt formation.
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORD
VOLUME76
ISSUE4
START_PAGE1159
END_PAGE1162
ABSTRACTAbsolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1021/jo102148p
FUNDING_BODY
GRANT_DETAILS