IRIS publication 160748018
Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram
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TY - JOUR - Croker, DM,Foreman, ME,Hogan, BN,Maguire, NM,Elcoate, CJ,Hodnett, BK,Maguire, AR,Rasmuson, AC,Lawrence, SE - 2012 - January - Crystal Growth ; Design - Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram - Validated - () - PHARMACEUTICAL COCRYSTALS CO-CRYSTALS - 12 - 869 - 875 - A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system. - DOI 10.1021/cg201300e DA - 2012/01 ER -
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@article{V160748018, = {Croker, DM and Foreman, ME and Hogan, BN and Maguire, NM and Elcoate, CJ and Hodnett, BK and Maguire, AR and Rasmuson, AC and Lawrence, SE }, = {2012}, = {January}, = {Crystal Growth ; Design}, = {Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram}, = {Validated}, = {()}, = {PHARMACEUTICAL COCRYSTALS CO-CRYSTALS}, = {12}, pages = {869--875}, = {{A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system.}}, = {DOI 10.1021/cg201300e}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Croker, DM,Foreman, ME,Hogan, BN,Maguire, NM,Elcoate, CJ,Hodnett, BK,Maguire, AR,Rasmuson, AC,Lawrence, SE | ||
YEAR | 2012 | ||
MONTH | January | ||
JOURNAL_CODE | Crystal Growth ; Design | ||
TITLE | Understanding the p-Toluenesulfonamide/Triphenylphosphine Oxide Crystal Chemistry: A New 1:1 Cocrystal and Ternary Phase Diagram | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
SEARCH_KEYWORD | PHARMACEUTICAL COCRYSTALS CO-CRYSTALS | ||
VOLUME | 12 | ||
ISSUE | |||
START_PAGE | 869 | ||
END_PAGE | 875 | ||
ABSTRACT | A novel 1:1 cocrystal between p-toluenesulfonamide and triphenylphosphine oxide has been prepared and structurally characterized. This 1:1 cocrystal was observed to form during solid state grinding experiments, with subsequent formation of a known 3:2 cocrystal in the presence of excess sulfonamide. Both cocrystals are stable in the solid state. The ternary phase diagram for the two coformers was constructed in two different solvents: acetonitrile and dichloromethane. Examination of these diagrams clarified solution crystallization of both the newly discovered 1:1 cocrystal and the previously reported 3:2 cocrystal, and identified regions of stability for each cocrystal in each solvent. The choice of solvent was found to have a significant effect on the position of the solid state regions within a cocrystal system. | ||
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DOI_LINK | DOI 10.1021/cg201300e | ||
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