IRIS publication 241769680
Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.
RIS format for Endnote and similar
TY - JOUR - Slattery CN, Deasy RE, Maguire AR, Kopach ME, Singh UK, Argentine MD, Trankle WG, Scherer RB, Moynihan H - 2013 - June - The Journal of Organic Chemistry - Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate. - Validated - () - 78 - 12 - 5955 - 5963 - An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup. - 10.1021/jo400647t DA - 2013/06 ER -
BIBTeX format for JabRef and similar
@article{V241769680, = {Slattery CN, Deasy RE and Maguire AR, Kopach ME and Singh UK, Argentine MD and Trankle WG, Scherer RB and Moynihan H }, = {2013}, = {June}, = {The Journal of Organic Chemistry}, = {Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.}, = {Validated}, = {()}, = {78}, = {12}, pages = {5955--5963}, = {{An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.}}, = {10.1021/jo400647t}, source = {IRIS} }
Data as stored in IRIS
AUTHORS | Slattery CN, Deasy RE, Maguire AR, Kopach ME, Singh UK, Argentine MD, Trankle WG, Scherer RB, Moynihan H | ||
YEAR | 2013 | ||
MONTH | June | ||
JOURNAL_CODE | The Journal of Organic Chemistry | ||
TITLE | Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate. | ||
STATUS | Validated | ||
TIMES_CITED | () | ||
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VOLUME | 78 | ||
ISSUE | 12 | ||
START_PAGE | 5955 | ||
END_PAGE | 5963 | ||
ABSTRACT | An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup. | ||
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DOI_LINK | 10.1021/jo400647t | ||
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