Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.

Typeset version

 

TY  - JOUR
  - Slattery CN, Deasy RE, Maguire AR, Kopach ME, Singh UK, Argentine MD, Trankle WG, Scherer RB, Moynihan H
  - 2013
  - June
  - The Journal of Organic Chemistry
  - Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.
  - Validated
  - ()
  - 78
  - 12
  - 5955
  - 5963
  - An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.
  - 10.1021/jo400647t
DA  - 2013/06
ER  - 
@article{V241769680,
   = {Slattery CN,  Deasy RE and  Maguire AR,  Kopach ME and  Singh UK,  Argentine MD and  Trankle WG,  Scherer RB and  Moynihan H },
   = {2013},
   = {June},
   = {The Journal of Organic Chemistry},
   = {Telescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.},
   = {Validated},
   = {()},
   = {78},
   = {12},
  pages = {5955--5963},
   = {{An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.}},
   = {10.1021/jo400647t},
  source = {IRIS}
}
AUTHORSSlattery CN, Deasy RE, Maguire AR, Kopach ME, Singh UK, Argentine MD, Trankle WG, Scherer RB, Moynihan H
YEAR2013
MONTHJune
JOURNAL_CODEThe Journal of Organic Chemistry
TITLETelescoped approach to aryl hydroxymethylation in the synthesis of a key pharmaceutical intermediate.
STATUSValidated
TIMES_CITED()
SEARCH_KEYWORD
VOLUME78
ISSUE12
START_PAGE5955
END_PAGE5963
ABSTRACTAn efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1021/jo400647t
FUNDING_BODY
GRANT_DETAILS