Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate

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TY  - JOUR
  - Slattery, CN,Deasy, RE,Maguire, AR,Kopach, ME,Singh, UK,Argentine, MD,Trankle, WG,Scherer, RB,Moynihan, H
  - 2013
  - June
  - The Journal of Organic Chemistry
  - Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate
  - Validated
  - WOS: 10 ()
  - GRIGNARD-REAGENTS FORMYLATION EXCHANGE
  - 78
  - 5955
  - 5963
  - An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.
  - 10.1021/jo400647t
DA  - 2013/06
ER  - 
@article{V243945282,
   = {Slattery,  CN and Deasy,  RE and Maguire,  AR and Kopach,  ME and Singh,  UK and Argentine,  MD and Trankle,  WG and Scherer,  RB and Moynihan,  H },
   = {2013},
   = {June},
   = {The Journal of Organic Chemistry},
   = {Telescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate},
   = {Validated},
   = {WOS: 10 ()},
   = {GRIGNARD-REAGENTS FORMYLATION EXCHANGE},
   = {78},
  pages = {5955--5963},
   = {{An efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.}},
   = {10.1021/jo400647t},
  source = {IRIS}
}
AUTHORSSlattery, CN,Deasy, RE,Maguire, AR,Kopach, ME,Singh, UK,Argentine, MD,Trankle, WG,Scherer, RB,Moynihan, H
YEAR2013
MONTHJune
JOURNAL_CODEThe Journal of Organic Chemistry
TITLETelescoped Approach to Aryl Hydroxymethylation in the Synthesis of a Key Pharmaceutical Intermediate
STATUSValidated
TIMES_CITEDWOS: 10 ()
SEARCH_KEYWORDGRIGNARD-REAGENTS FORMYLATION EXCHANGE
VOLUME78
ISSUE
START_PAGE5955
END_PAGE5963
ABSTRACTAn efficient synthetic approach leading to introduction of the hydroxymethyl group to an aryl moiety via combination of the Bouveault formylation and hydride reduction has been optimized using a rational, mechanistic-based approach. This approach enabled telescoping of the two steps into a single efficient process, readily amenable to scaleup.
PUBLISHER_LOCATION
ISBN_ISSN
EDITION
URL
DOI_LINK10.1021/jo400647t
FUNDING_BODY
GRANT_DETAILS