Transforming our food systems for sustainability and resilience is pertinent and urgent to achieve the EU Green Deal goals. The food system is highly complex, characterised by uncertainty, multiple drivers, impacts and interconnected sectors, requiring trade-offs. Therefore, acting simultaneously on many fronts is the only key to success. This is why Agrinatura and many other researchers are advocating for a new systems approach to understand the challenges and to target transformational change through a coherent set of policies, initiatives, and investments.