1995 …2025

Research activity per year

Personal profile

Biography

Professor Anne Moore holds a joint position between the School of Biochemistry and Cell Biology, UCC and the National Institute of Bioprocessing Research and Training (NIBRT). She completed a PhD in HIV vaccine immunology with Professor Kingston Mills and subsequently embarked upon post-doctoral work on defects in immune responses in HIV-infected individuals in the Wistar Institute in Philadelphia and further work on vaccines against viruses such as HIV and Ebola virus in Dr. Gary Nabel's lab, then at the University of Michigan. As a senior immunologist in Prof. Adrian Hill's group in the University of Oxford, she developed several vaccine candidates against malaria, TB and influenza virus. In UCC, Prof Moore moved from a lectureship in Pharmacology, based in the School of Pharmacy, UCC, to a senior lectureship in Biochemistry in 2018. She has won several awards, including leading the UCC Research Team of the Year in UCC in 2012. She undertook a sabbatical in a US vaccine biotech company, Vaxart in 2016. Here she worked on tablet-based oral vaccines for a range of therapeutic and prophylactic vaccine. Prof. Moore's research focus is to enhance vaccine accessibility and acceptability. She and her research group use both vaccine development strategies as well as qualitative research methodologies to advance these research aims.

Research Interests

My research vision is to protect people against infectious diseases, equitably across the world, by increasing vaccine coverage and effectiveness. Our research is inter- and trans-disciplinary by nature. My research mission is to develop effective interventions to improve vaccine effectiveness, primarily by translating innovative and advanced vaccines to address equitable access and acceptability needs and, secondarily, by understanding people’s acceptability of vaccines. My research extends from basic immunology and vaccine formulation to clinical translation and vaccine acceptance and confidence. Some currently funded projects include a focus on understanding how the vaccine delivery technology impacts on the breadth of the immune response in a relevant large animal model; developing novel vaccines to tackle anti-microbial resistance and developing vaccine-based microarray patches for injection-free ease of use and ease of deployment. VACCINE DELIVERY: Vaccination has been fundamental in the control of infectious diseases, however effective immunization programmes are still lacking for many diseases, including emerging infectious diseases that have resulted in epidemics and pandemics. This has resulted in significant global morbidity and mortality. Inadequate deployment of vaccines has resulted in millions of children not receiving enough doses of all vaccines to fully protect them. Logistic constraints in vaccine manufacture, cold chain and the need for injection are being addressed by developing new vaccines and delivery technologies. My group aims to develop technical solutions to improve vaccine deployment A core research aim is to address vaccine logistic issues by developing thermostable, easy-to-administer, needle-free alternatives. My group are developing a stabilising vaccine technology, based on d

Teaching Activities

BC3005: Biochemical Immunology (module co-ordinator). BC4008: Immunochemistry, Health and Disease (module co-ordinator). BC4022: Immunobiology of Health and Disease BC6001: Cell and Molecular Biology (module co-ordinator). ML6006: Human Molecular Genetics and Genetic Engineering Techniques Previously: PT6401: Pharmacology for M.Sc. in Pharmaceutical Technology and Quality Systems (module co-ordinator) PT2448: Molecular Pharmacology (module co-ordinator) PT1445: Foundation PharmacologyPostgraduate (module co-ordinator) PF2011: Research Methods (module co-ordinator) PF3012: Respiratory, Musculoskeletal and Dermatology Systems PF3009: Gastrointestinal, Hepatic and Endocrine Systems External Examiner: 2014: Leiden University, NL, Ph.D. thesis. Koen van dar Maaden: Microneedle-mediated vaccine delivery 2014: Waterford Institute of Technology: Ph.D. thesis, Jennifer Morrissey, The Development of Novel Dermal Translocation, High Potency Drug Delivery Systems. Internal Examiner: 2014: School of Microbiology, UCC, Ph.D. thesis, Ludovica Butto; Immunomodulatory Effects Exerted by Lactobacillus salivarius Strains on Innate Immune Cells 2013: Trinity College Dublin, M.Sc. thesis, Fiona Crowe, The Regulation of CD25 Surface Expression 2012: Trinity College Dublin Ph.D. thesis; Gillian Muirhead, Niemann Pick Type C Disease. 2012: Dept. Obstetrics and Gyneacology, UCC. MD thesis, Uzma Mahmood, Fetal Microchimerism and Maternal Wound healing. External Examiner for U. Glasgow Immunology Degree rese

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

UCC Futures (primary)

  • Future Pharmaceuticals

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