Personal profile
Biography
I am currently a Senior Lecturer in Biochemical Engineering at University College Cork (Ireland), holding a joint appointment in the School of Microbiology and the School of Engineering & Architecture. I was trained in Bioprocess Engineering and Biotechnology at the Federal University of Paraná (Brazil), where I graduated with the highest GPA of the year. I completed my PhD at the Otto von Guericke University Magdeburg in cooperation with the Max Planck Institute for Dynamics of Complex Technical Systems (Germany), with my thesis on Simulated Moving Bed Chromatography awarded the highest honours. I was subsequently awarded a competitive FAPESP individual postdoctoral fellowship in Quality by Design (QbD) led biopharmaceutical process development at the University of São Paulo (Brazil), followed by an Instrument Scientist role overseeing the Bernal Bio Labs at the University of Limerick (Ireland).
My current research focuses on the development of sustainable biomanufacturing processes to support the circular bioeconomy. My research integrates QbD and Safe & Sustainable by Design principles to create robust and scalable processes, with a particular emphasis on the development of Digital Twins of bioprocesses for optimisation and control. A key strand of my work is the integration of AI/ML into the control and optimisation of precision fermentation processes, linking advanced modelling, Data Science and Experimental Design to accelerate innovation in industrial biotechnology.
Research Interests
My research interests focus on developing sustainable biomanufacturing within the circular bioeconomy. I work on hybrid mechanistic and data-informed models, bioprocess scale-up, and QbD-driven bioprocess development supported by Process Analytical Technology (PAT), control and optimisation, as well as Bayesian Inference and uncertainty analyses. I am particularly interested in the development of Digital Twins and AI/ML-enabled control strategies for Precision Fermentation, with applications in sustainable industrial bioprocesses for the production of biopharmaceuticals, foods, platform chemicals, and high-value ingredients.
Teaching Activities
I currently coordinate and contribute to modules in Experimental Design and Data Analysis, Sustainable Biochemical Engineering, Biopharmaceutical Engineering, Bioprocess Design, Manufacturing Excellence, and Microbial Physiology in Bioreactors across the Schools of Microbiology and Engineering & Architecture at UCC. I integrate Statistical Experimental Design, Process Modelling, and Digital Tools, including elements of Data Science and Process Analytical Technology, to connect fundamental Microbiology and Engineering with real bioprocess challenges in industry. I also supervise undergraduate and postgraduate research projects and dissertations, using authentic, research-led and industry-informed problems to prepare students for advanced biomanufacturing and the circular bioeconomy.
UCC Futures (primary)
- Future of Sustainable Fermentation (SUSFERM)
PhD Supervision
- Available for PhD supervision
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 7 Affordable and Clean Energy
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SDG 8 Decent Work and Economic Growth
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 11 Sustainable Cities and Communities
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SDG 12 Responsible Consumption and Production
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SDG 15 Life on Land
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Collaborations and top research areas from the last five years
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A roadmap for model-based bioprocess development
Mu'azzam, K., Santos da Silva, F. V., Murtagh, J. & Sousa Gallagher, M. J., 1 Jul 2024, In: Biotechnology Advances. 73, 108378.Research output: Contribution to journal › Review article › peer-review
Open Access -
Carryover analysis by liquid chromatography mass spectrometry in a multiproduct resin reuse context
Helle, S., Santos da Silva, F. V., McAvinue, J., Coffey, L., Arthur, A., Cawley, J., Brophy, M., O'Neill, A., Sheehy, M., Kelly, R. M., Ahern, T., Osborne, M. D., Horgan, C. P., Foley, D., Hayes, R., Monaghan, D., O'Brien, P., Mahon, J. & Hudson, S. P., Nov 2024, In: Process Biochemistry. 146, p. 547-559 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
6. Desenvolvimento de processos de produção de biofármacos de acordo com Quality by Design (QbD)
Santos da Silva, F. V., 2023, Processos de Purificação de Bioativos para a Indústria Farmacêutica. Costapinto, C. & Álvaro, L. S. S. (eds.). 1 ed. Farolândia: EDITORA UNIVERSITÁRIA TIRADENTES, p. 203-231 29 p.Research output: Chapter in Book/Report/Conference proceedings › Chapter
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Enhanced production of N-acetyl-glucosaminidase by marine Aeromonas caviae CHZ306 in bioreactor
Cardozo, F. A., Feitosa, V., Mendonça, C. M. N., da Silva, F. V. S., Converti, A., de Souza Oliveira, R. P. & Pessoa, A., Sep 2023, In: Brazilian Journal of Microbiology. 54, 3, p. 1533-1545 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Characterization of Lactiplantibacillus plantarum Tw226 strain and its use for the production of a new membrane-bound biosurfactant
Lara, V. M., Mendonça, C. M. N., Silva, F. V. S., Marguet, E. R., Vallejo, M., Converti, A., Varani, A. M., Gliemmo, M. F., Campos, C. A. & Oliveira, R. P. S., 1 Oct 2022, In: Journal of Molecular Liquids. 363, 119889.Research output: Contribution to journal › Article › peer-review
Open Access