Harriet Schellekens

Senior Lecturer

20032026

Research activity per year

Personal profile

Biography

Dr. Harriët Schellekens is a Senior Lecturer in the Department of Anatomy & Neuroscience, a Principal Investigator with Food for Health Ireland (FHI), and a funded investigator with the APC Microbiome Ireland. Dr. Schellekens is an Associate Editor for Nutritional Neuroscience (February 2021) and an Editorial Board Member of Neuropharmacology (August 2020). Dr. Schellekens is in the top 0.1% of scholars writing about Ghrelin over the past 10 years, a level we label as "World Expert" (Expertscape's PubMed-based algorithms).· Dr Schellekens research is focused on the microbiome-gut-brain axis in nutritional neuroscience and psychiatry. Her group investigates impact of diet & nutrition and the gut microbiome on human metabolic and mental health across the lifespan. She has designed and runs a screening platform for the mechanistic mining of gut microbiota across gut-brain axis targets to identify effective biotherapeutics and microbiota-targeted strategies against obesity and stress. She received a PhD in Pharmacy from the University College Cork, Ireland in 2012 and a MSc in Biology and Medical Biology (Hons) from the Radboud University in Nijmegen, The Netherlands. She was awarded a Marie Curie Host Fellowship for Transfer of Knowledge (TOK) in 2006. She has gained considerable expertise in the pharmaceutical industry in RESE

Research Interests

Dr. Schellekens investigates the impact of diet & nutrition and the gut microbiome on human health and physiology, in particular in the context of metabolic health and mental health throughout life. Her research interests have been focused on the neuronal circuitry and gut-brain axis signaling, underlying the complex relationship between stress, mood and food intake. She uses mechanistic and translational studies bridging basic and clinical aspects of neuroscience and nutrition to investigate the concept of the link between metabolic disease and stress-related disorders, and the potential amelioration of both via microbiome-targeted approaches. Research focus: MECHANISM of microbiota-gut-brain and immune-neuroendocrine signaling in regulation of appetite, food reward, feeding behavior, and metabolic response to stress. PHARMACOLOGY and crosstalk of G-protein coupled receptors (GPCRs), neuropeptides and gut hormones across the gut-brain axis.TRANSLATIONAL impact of diet & nutrition and the gut microbiome in obesity, diabetes and stress.Dr. Schellekens has, through in vitro, ex vivo and in vivo approaches, significantly contributed to the understanding of signalling through the ghrelin receptor, a key receptor modulating appetite, food intake, glucose homeostasis, reward-signalling and stress. In particular, her work has focused on the pharmacology of centrally expressed G-protein coupled receptors (GPCRs), neuropeptides and gut hormones within the microbiota-brain-gut axis, regulating the homeostatic control of food intake. In addition, these appetite and satiety signals also modulate the hedonic aspects of food intake and impact on stress-induced food reward behavior, which play a major role in the development of eating disorders, including obesity, binge-eating and addiction. Harriet is experie

Teaching Activities

Module Teaching (lectures and practicals): Dr. Schellekens teaches and has taught a diverse range of topics (Neuroscience, Neuroanatomy, Pharmacy, Medicine) to various groups of students. Specific modules she has taught or coordinated are; Cellular and Molecular Neuroscience(AN4014), Human Nervous System (AN3012), Research Methodology in Neuroscience (AN3001), Developmental Neurobiology (AN4008), Foundations of Medicine, Neuroscience (FM2101), Neuropharmacology (PT4005), Advanced Basic and Clinical Pharmacology (PT3445), Introduction to Pharmacology (PT3001), Foundations of Medicine, Fundamentals of Therapy (FM3003), Fundamentals of Medicine IV , Neuroanatomy (GM2001), Neurobiology of disease (AN3013), and Master students in Clinical perscpectives of human disease (ML6002). Supervision of undergraduate research projects: Dr. Schellekens has supervised final year BSc Neuroscience laboratory research projects (AN4010), intercalated Medical degree research projects (AN4011), and library projects (AN3011) to BSc Neuroscience students. In addition, she has also supervised 4th year Pharmacy student projects. Moreover, each year she mentors B.Sc students for their final year project varying from 5 to 9 month durations from the Avans University, The Netherlands. Teaching Qualification: 2013: Anatomy Training Program, Anatomical Society, Oxford, UK (ongoing)2015: Postgraduate Certificate in Teaching and Learning in Higher Education (scheduled) Current Postgraduates students:Dalia Kandil, Structured PhD studentRory O'Connor, Structured PhD studentKen Howick, Structured PhD studentAnna Cristina Connolly, Structured MSc studentSurabhi Dasan Theratile, Structured MSc student

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 4 - Quality Education
    SDG 4 Quality Education

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