Personal profile
Biography
Research Interests
My research programme is fundamentally centred on the discovery of biologically relevant molecular pathways and diagnostic biomarkers for complex neuropsychiatric and neurodevelopmental conditions. The primary goal is to translate these discoveries into clinical tools that improve health outcomes.
My specific research interests include:
- Biomarker Discovery for Neurodevelopmental Disorder: Identifying protein and metabolite biomarkers of Autism in neonatal cord blood (PMID: 40962828)
- Placental Biology: We are exploring the placenta as a key interface between the maternal and fetal environments, and a potential source of biomarkers, providing further insights into altered perinatal and neurodevelopmental trajectories.
- Biomarker Discovery Maternal/Perinatal Health: Collaborative metabolomics research in Preterm Birth (PMID: 31974687), Fetal Growth Restriction (PMID: 33398476), Pre-eclampsia (PMID: 32231385).
- Advanced Mass Spectrometry Workflows: Developing and applying advanced proteomic, metabolomic and bioinformatic methods for studying complex biological systems in health and disease. These expertise provide a direct and powerful methodological bridge to collaborative research in the areas of gut-brain axis, Alzheimer's disease, and clinical biomarker discovery (PMID: 38508906, PMID: 37849234, PMID:40153830; PMID: 39532277; PMID: 38658547).
UCC Futures (primary)
- Children
Other research affiliations
- UCC Futures - Artificial Intelligence and Data Analytics
- UCC Futures - Future Ageing and Brain Science
PhD Supervision
- Available for PhD supervision
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Chronic low-grade hippocampal inflammation blunts exercise-induced neurogenesis and alters the exercise-induced microglia transcriptome in the rat hippocampus
Nicolas, S., Caruso, M. G., Dohm-Hansen, S., Foley, T., Lucassen, P. J., Mul, J. D., Lavelle, A., English, J. E., O'Leary, O. F. & Nolan, Y. M., 23 May 2026, (E-pub ahead of print) In: Brain, Behavior, and Immunity. p. 106815Research output: Contribution to journal › Article › peer-review
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Differential effects of wheel running and treadmill exercise on spatial memory, adult hippocampal neurogenesis and the cerebrospinal fluid proteome in rats
Caruso, M. G., Dohm-Hansen, S., Donoso, F., Rynikova, M., Lavelle, A., English, J. A., Nicolas, S., O'Leary, O. F. & Nolan, Y. M., 9 Apr 2026, (E-pub ahead of print) In: Neuropharmacology. p. 110956Research output: Contribution to journal › Article › peer-review
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Exercise induces changes in tryptophan metabolism by gut microbes associated with hippocampal function in adult rats
Caruso, M., Dohm-Hansen, S., Williams, Z. A. P., English, J., Lavelle, A., Nicolas, S., O'Leary, O. & Nolan, Y., 10 Mar 2026, In: Brain Medicine.Research output: Contribution to journal › Article › peer-review
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Expanding the Proteomics and Metabolomics Toolkit with Methods for Differential Expression Analysis from Transcriptomics
Dohm-Hansen, S., Caruso, M. G., Nicolas, S., Scaife, C., O'Leary, O. F., Nolan, Y. M., Lavelle, A. & English, J. A., 6 Mar 2026, In: Journal of Proteome Research. 25, 3, p. 1253-1264 12 p.Research output: Contribution to journal › Article › peer-review
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Rasal1: A candidate exercise mimetic to increase adult hippocampal neurogenesis in middle age
Nolan, Y., Caruso, M. G., Dohm-Hansen, S., Nicolas, S., English, J., Lavelle, A., Lucassen, P., Mul, J. & O'Leary, O., 13 Feb 2026Research output: Other output
Press/Media
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Fine-bubble engineering: A fresh and economic appraisal to redesigning liquids’ life-line to bioprocesses
6/01/25
1 item of Media coverage
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Electric-field nanobubbles: A step change in nanobubble engineering, and its “coming of age”
3/10/24
1 item of Media coverage
Press/Media