John V (Eoin) Fleming

Dr Eoin (J.V.) Fleming is a lecturer in Biochemistry and Cell Biology in University College Cork, and Director of several postgradaute courses delivered to the BioPharmaceutical sector. He graduated with an BSc(Hons) in Biochemistry from University College Cork in 1992. Therafter he completed studies for his PhD at the University of Aberdeen in 1996 and worked briefly on an industrial research contract with Rowett Research Services before moving to Boston where he was eemployed as a post-doctoral researcher at Harvard Medical School/ Massachussetts General Hospital (1998-2000). He served as a Research Assistant Professor at the University of Massachusetts Medical School (2000-2003), before employment as a Senior Scientist at the Institute of Molecular Medicine at the University of Lisbon, Portugal in 2004. He returned to Ireland in 2006 when he took up a joint appointment in the School of Biochemistry and the School of Pharmacy. Since then his research has focussed on the quality control of proteins at the endoplasmic reticulum, looking at the molecular factors underlying Hereditary Hemachromatosis and molecular regulation of ubiquitin conjugating enzymes. Total citations:1,213 h index: 16 i10 index: 19 Google Scholar link: ‪John V Fleming‬ - ‪Google Scholar‬ Total Career Research Income: €1,444,898 PhD graduated: 3 2024 - Emer Cantillon 2016 - Shuet Yin Selina Lam 2014

Research in my lab is focussed on the expression, function and degradation of ER associated proteins. Our published results relate to two proteins in particular, the histidine decarboxylase (HDC) enzyme that catalyzes the formation of histamine, and HFE, which is involved in regulating cellular iron metabolism. Treatment of histamine related diseases can conservatively be estimated to cost Irish patients many millions of euros every year, while the most common inherited disease in Ireland, hereditary haemachromatosis, is associated with mutations in the HFE gene. We are particularly interested in characterizing the manner in which these two proteins are degraded with the aim of providing new insights into how they are regulated physiologically, or how they could potentially be regulated pharmacologically.

I teach to Biochemistry students, including on modules BC4010 and BC4012. As a joint appointment between the Department of Biochemistry and the School of Pharmacy, I also have responsibility for co-ordinating the teaching of Biochemistry to Pharmacy student and lecture on a number of modules delivered to Pharmacy students including BC1443/ BC1024 (10 credits), PF3013 (5 credits), PF4106 (10 creedits), PF6210 (30 credits) and PF6423. I am Director on a number of Postgraduate BioPharm-related courses: MSc and PG Diploma in BioPharma Processing (Level 9, 30+60 credits) H.Dip in Design and Manufacture of BioPharmaceuticals (Level 8, 60 credits) CPD Cert microcred - BioPharmaceutical Techologies and Processes (Level 9, 10 credits) CPD Cert microcred- Introduction to BioPharmaceutical Procesing and Advanced Personalized Therapies (Level 8, 10 credits) In this role I am co-ordinator and lecturer on a number of modules, including PF6610 (10 credit), PF6612 (10 credit), PF6615 (5 credit), PF6616 (30 credits), BC5004 (10 credits), PF5003 (10 credits), BC5006 (15 credits).