Personal profile
Biography
Dr. Katja Burk studied biology at the University of Hohenheim (Stuttgart) and completed her diploma thesis at the Max-Planck-Institute for Neurobiology in Martinsried, Munich. She then moved to Cardiff, UK to obtain her PhD in developmental neurobiology, followed by two postdoctoral positions at the IBDML in Marseille, Luminy, France. Dr. Burk returned to Germany in 2014 on an independent grant from the German Academic Exchange Programme (DAAD) and the Dorothea Schlözer funding for a postdoctoral position at the European Neuroscience Institute (ENI) in Göttingen, a Joint Initiative of the University Medical Center Göttingen and the Max Planck Institute for Multidisciplinary Sciences. In 2017, Dr. Burk became a funded group leader within the DFG Cluster of Excellence “Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB)”, in Department of Neurology at the University Medical Center Göttingen. She received additional funding from the German research Council (DFG), The German Society for Neuromuscular Disease (DGM) as well as from the Heidenreich von Siebold funding which supports academics on their path to their Habilitation. In July 2022 Dr. Burk was appointed as a lecturer in the School of Biochemistry and Cell Biology at UCC. In 2023, Dr. Burk completed her Habilitation at the Georg-August University Göttingen in developmental neurobiology and the Burk lab moved full time to UCC.
At UCC, Dr. Burk and her team are working mainly on motor neuron disease and neuropathies, using induced pluripotent stem cells, high-resolution microscopy and biochemistry. To conduct this work, Dr. Burk and her lab has received funding from UCC/SEFS, the Motor Neurone Disease Association (MNDA), the Irish Research Council (IRC) and the Higher Education Authority (HEA).
Dr. Burk reviews for several grant agencies and it a member of the Med5 PhD and the Med5 Postdoc panel for Research Foundation Flanders.
Research Interests
By training, Dr. Burk is a developmental neurobiologist and for many years, her research focussed on axon guidance mechanisms, neuronal survival and synapse formation. Dr. Burk has specific expertise on how activated receptors traffic and transmit their signals within neurons, an essential process during development and – if this process is failing- in neurodegeneration.
At UCC, the current research builds on this expertise by studying the failing cellular mechanisms that lead to neuropathies and motor neuron disease such as Charcot-Marie-Tooth disease and Amyotrophic Lateral Sclerosis. To study such mechanisms, the lab currently focusses on human models using iPSC-derived sensory and motor neurons, but the lab also has expertise in primary neurons from rat, mouse and chick. The lab has expertise in imaging techniques (e.g. confocal, total internal reflection fluorescence (TIRF), stimulated emission depletion (STED), electron- or spinning-disk microscopy) and biochemistry.
Teaching Activities
External positions
Group Leader, University Medical Center Göttingen
1 Jul 2017 → 31 Dec 2023
Postdoc, University Medical Center Göttingen
1 Sep 2014 → 1 Jun 2017
Postdoc, Institut de Biologie du Développement de Marseille (IBDM)
28 Feb 2010 → 31 Aug 2014
PhD , Cardiff University
1 May 2005 → 31 Jan 2010
Diploma Student, Max Planck Institute of Neurobiology
1 Feb 2004 → 30 Apr 2005
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Collaborations and top research areas from the last five years
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Axon Guidance Receptor Endocytosis, Trafficking, and Signaling in Health and Disease
Bues, B., O’Mahony, K. R. & Burk, K., 2025, The Receptors.Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review
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Condensate Formation of the Human RNA-binding Protein SMAUG1 is Controlled by its Intrinsically Disordered Regions and Interactions with 14-3-3 Proteins
Carey, O., Fehilly, J., O'Leary, E. T., O'Shea, S., Juda, K., Fitzel, R., Selvaraj, P., Burk, K., Lindsay, A. J., Young, P., Pancsa, R., Mészáros, B. & Dean, K., 1 Oct 2025, In: Journal of Molecular Biology. 437, 19, 169314.Research output: Contribution to journal › Article › peer-review
Open Access -
The sorting, trafficking, signaling and signal-diversification of neurotrophic- and axon guidance receptors: Habilitation Thesis Georg-August University Göttingen, Germany
Burk, K., 2024, 250 p.Research output: Other output › peer-review
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The endocytosis, trafficking, sorting and signaling of neurotrophic receptors.
Burk, K., 2023, Progress in Molecular Biology and Translational Science. Elsevier, Vol. 196. p. 141-165Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review
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Axon guidance receptors: Endocytosis, trafficking and downstream signaling from endosomes
Pasterkamp, R. J. & Burk, K., Mar 2021, In: Progress in Neurobiology. 198, 101916.Research output: Contribution to journal › Review article › peer-review
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“Ataxin2 affects transcription of neurofilaments and causes cytoskeletal defects”
Burk, K. (Speaker)
2025Activity: Talk or presentation › Invited talk
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School of Biochemistry and Cell Biology (Organisational unit)
Burk, K. (Chair)
2024 → …Activity: Membership › Membership of committee
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University College Cork (Organisational unit)
Burk, K. (Member)
2024 → …Activity: Membership › Membership of committee
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“Investigating CMT2B pathomechanisms in a human iPSC-derived model”
Burk, K. (Speaker)
2023Activity: Talk or presentation › Oral presentation
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“induced pluripotent stem cells as a model system for Charcot-Marie-Tooth Disease”
Burk, K. (Speaker)
2023Activity: Talk or presentation › Invited talk