2011-present Professor of Physiology, UCC. 2006-2011 Senior Lecturer, University College Dublin (UCD). 2000-2006 Lecturer, UCD. 1996-2000 Postdoctoral Fellow, UW-Madison, USA. 1995-1996 Postdoctoral Fellow, UNC Chapel Hill, USA. 1992-1995 PhD, RCSI & UCD (HRB-funded). 1988-1992 BSc (Hons) Physiology, UCC. University Roles 2015-present Research Integrity Officer 2011-present Director, Biological Services Unit 2011-present Head, Department of Physiology External Roles 2019-2025 Senior Editor, The Journal of Physiology 2015-2025 Senior Editor, Experimental Physiology 2014-2017 Meetings Secretary, The Physiological Society 2014-2017 Executive Committee, The Physiological Society 2012-2017 Trustee & Council Member, The Physiological Society 2011-2019 General Secretary, Royal Academy of Medicine in Ireland 2013-2015

The major focus of our research is cardio-respiratory function in health and disease. I am an integrative physiologist with diverse research interests and experience ranging from cardio-respiratory to gastrointestinal and renal physiology. Projects span the research landscape, including basic and applied research, patient-orientated research including observational and interventional studies in clinical populations as well as randomised-controlled trials, and field studies of cardio-respiratory and renal physiology at high altitude in sea-level natives (lowlanders). My research employs classical and contemporary multi-disciplinary experimental approaches and technologies in physiology, proteomics, redox biology, cell signalling, neuroscience, and respiratory medicine to explore the control of breathing and blood pressure in health and disease, in a variety of species, from genes to behaviour. Current interests: Therapeutic strategies to protect respiratory performance in mouse models of Duchenne muscular dystrophy. We performed the first comprehensive assessment of respiratory system performance in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our studies have revealed deficits and compensations at multiple sites in the integrative control of the respiratory musculature. We have demonstrated the efficacy of novel pharmacotherapy strategies and recently demonstrated that accessory muscles of breathing afford remarkable compensation for diaphragm muscle weakness in the dystrophic mouse, which we demonstrated is lost with progressive disease. This finding has implications for treatments and rehabilitative interventions in people with DMD. We are currently characterising the elaboration of respiratory system impairments in progressive dystrophic disease models, wherein we are exploring the efficacy of novel therapeutic

Undergraduate FM 1030 / MH 1030: Respiratory Biology & Metabolism MH 1050: Introduction to Translational Medicine PL 3001: Pathophysiology PL 3025: Literature Review, Experimental Design and Data Analysis PL 3022: Respiratory Physiology AN 3003: Neurobiology of Regulatory Systems MH 3010: Systematic Literature Review PL 4010: Control of Breathing in Health & Disease PL 4015: Microbiome & Physiology PL 4020: Research Project (final year BSc Physiology) MH 4010: Research Project (final year BSc Medicine & Health) Postgraduate DS 7100: Basic Science Relevant to Oral Surgery Practice PL 6008: Biological Systems for Clinical Physiologists: Respiratory function Research Postgraduates Anthony Marullo, PhD candidate Ben Murphy, PhD candidate Anna O'Connell, PhD candidate (primary supervisor Dr. Fiona McDonald) Dr Peter Leahy, MD candidate Ciaran Heatley, PhD candidate (primary supervisor Dr Dervla O'Malley)