Personal profile
Biography
Professor Noel Caplice is Professor of Cardiovascular Sciences in the Department of Medicine and Director of the Centre for Research in Vascular Biology at University College Cork. He is also a Consultant Cardiologist at Cork University Hospital. He previously held professional positions in pharmacology and medicine at the Mayo Clinic, Rochester, Minnesota, USA, where he was an interventional cardiologist and directed the Vascular Stem Cell Laboratory. Professor Caplice Centre for Research in Vascular Biology research programme is addressing fundamental questions in vascular stem cell biology, atherosclerosis and vascular remodeling with emphasis on translation of ideas to the clinical cardiology arena in areas of novel diagnostics and therapeutics in the field of stem cells, gene delivery and tissue engineering.
Research Interests
1. Detection of human smooth muscle progenitor cells in blood and human atherosclerotic plaque. 2.Determinatiing the cardiac repair potential of specific cytoprotective factors in models of myocardilal infarction3. Realtime tracking of stem cells in vivo and evaluation of paracrine cardiomyocyte repair effects of progenitor cells 4. Biology of vacsular progenitor cells and smooth muscle progenitor cells in animal models of atheroaclerosis, graft engineering, remodeling after stent injury and myocardial infarction
Teaching Activities
Undergraduate and graduate medical students-clinical cardiologyDoctorate and postdoctorate science graduates-vascular biology Core interests are in the areas of interventional cardiology as it relates to cardiac repair, vascular biology, vascular disease, translational medicine and novel therapeutics
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Collaborations and top research areas from the last five years
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Artificial intelligence-assisted left ventricular global longitudinal strain assessment in patients with acute myocardial infarction: a RESUS-AMI trial sub-analysis
Mekonnen, D., Spitzer, E., McFadden, E. P., Caplice, N. M. & Ren, C. B., Jun 2025, In: International Journal of Cardiovascular Imaging. 41, 6, p. 1225-1236 12 p.Research output: Contribution to journal › Article › peer-review
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Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome
Herisson, F. M., Cluzel, G. L., Llopis-Grimalt, M. A., O'Donovan, A. N., Koc, F., Karnik, K., Laurie, I., Canene-Adams, K., Ross, R. P., Stanton, C. & Caplice, N. M., Jan 2025, In: JACC: Basic to Translational Science. 10, 1, p. 1-15 15 p.Research output: Contribution to journal › Article › peer-review
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Gut Microbiota and Specific Response to Diet
Amamou, A., O’Mahony, C., Lopis-Grimalt, M. A., Cruzel, G., Caplice, N., Herisson, F. & Ghosh, S., 2024, Endocrinology (Switzerland). Springer Nature, p. 431-459 29 p. (Endocrinology (Switzerland); vol. Part F2257).Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review
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Use of derivative diffuse reflectance spectroscopy in CAM assay combined with multivariate analysis as an approach to detect features of vulnerable plaques
Lu, H., O'Dowling, C., Caplice, N. M., Burke, R. & Andersson-Engels, S., 2023, Diffuse Optical Spectroscopy and Imaging IX. Contini, D., Hoshi, Y. & O'Sullivan, T. D. (eds.). SPIE, 126281L. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 12628).Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review
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Use of derivative diffuse reflectance spectroscopy in CAM assay combined with multivariate analysis as an approach to detect features of vulnerable plaques
Lu, H., O’Dowling, C., Caplice, N. M., Burke, R. & Andersson-Engels, S., 2023.Research output: Contribution to conference › Paper › peer-review
Press/Media
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UCC spin-out ProVascTec secures €2.5m DTIF funding for breakthrough vascular therapy
3/10/25
1 item of Media coverage
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Innovative blood treatment developed in Cork could prevent blockages leading to amputations
3/10/25
1 item of Media coverage
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