Personal profile
Biography
Dr. Sharon McKenna graduated from the University of Leicester in 1990 with an Honours Degree in Molecular Biology. She obtained her PhD at the Leukaemia Research Fund Laboratories, in the University of Wales, College of Medicine, Cardiff, UK 1995. Following post-doctoral research at Cardiff and the Department of Biochemistry, UCC, Dr. McKenna was appointed College Lecturer in the Department of Biochemistry, UCC in 1999. She lectured on various aspects of Biochemistry and the Molecular Basis of Disease to undergraduate Science, Medical and Dental students. Dr. McKenna was also group leader of the Signal Transduction Laboratory. In 2002, Dr. McKenna was appointed as a Principal Investigator at the Cork Cancer Research Centre (CCRC). She is responsible for the direction of the Autophagy program and is also responsible for the supervision of graduate research projects including PhD’s and MD/PhD’s.
Research Interests
Dr McKenna is responsible for the direction of the Autophagy program at CCRC. Her team is investigating how autophagy influences response to chemotherapy, how to improve therapeutic regimes with novel targeting strategies and how to predict response to therapy with novel bio-markers. Her focus is on cancers with a relatively poor prognosis such as oesophageal, ovarian and AML.
Teaching Activities
Engaged in research led post-graduate teaching. Masters, MD's and PhDs.
UCC Futures (primary)
- Cancer Research @ UCC
Other research affiliations
- UCC Futures - Future Medicines
PhD Supervision
- Available for PhD supervision
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Inhibition of USP18 in the presence of IFN-α elevates apoptosis, autophagy, and chemosensitivity of oesophageal cancer cell lines
Carey, M. M., O'Donovan, T. R., Coveney, C. M. & McKenna, S. L., 1 Oct 2025, In: Experimental Cell Research. 452, 2, 114768.Research output: Contribution to journal › Article › peer-review
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Expression of MxA in esophageal cancer cell lines can influence sensitivity to chemotherapeutic agents but this does not require apoptosis
Hayes, R. M., O'Donovan, T. R. & McKenna, S. L., Sep 2024, In: Cancer Medicine. 13, 17, e70173.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of cytotoxic activity of epigenetic drugs in oesophageal squamous cell carcinoma
Cassidy, R., Mckenna, S. & Barry, O. P., 2023, In: European Journal of Medical and Health Sciences. .Research output: Contribution to journal › Article › peer-review
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All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism
Benjamin, D. N., O’Donovan, T. R., Laursen, K. B., Orfali, N., Cahill, M. R., Mongan, N. P., Gudas, L. J. & McKenna, S. L., 24 Feb 2022, In: Frontiers in Oncology. 12, 848517.Research output: Contribution to journal › Article › peer-review
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Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients
El Mashed, S., O’Donovan, T. R., Kay, E., O’Grady, A., McManus, D., Turkington, R. C. & McKenna, S. L., Dec 2022, In: BMC Cancer. 22, 1, 908.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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Could using lithium help cure cancer?; Research by scientists in Cork could change outcomes for millions all over the world More and more patients are Ireland on a daily basis, and re diagnosed with cancer in nd we need to extend their lives
Mckenna, S., Corrigan, M., O'Reilly, S. & O'Donovan, T.
8/02/22
1 item of Media coverage
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IRISH BOFFINS CANCER DRUG BREAKTHROUGH; Research into why some tumours fail to respond delivers new chemo
5/02/22
1 item of Media coverage
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