Personal profile
Biography
Dr Stuart Collins received his BSc. Degree in Chemistry, UCC in 1998 and then did his PhD. in Organic Chemistry at UCC under the supervision of Prof. Anita Maguire entitled "alpha-Diazosulfoxides-Synthesis and Transformations to alpha-Oxo Sulfines." He decided to follow an academic career path and worked on two Postdoctoral Research projects, the first on development of novel methodology for the synthesis of phosphononucleosides as antiviral agents (University College Cork and Tanaud Inc. Ireland) and the second on the asymmetric synthesis of unnatural amino acids (University College Cork and the Conway Institute University College Dublin). He was appointed as a Lecturer in Organic and Pharmaceutical Chemistry in UCC in 2007 and became a Senior Lecturer in 2019. He is currently the Director of the BSc Chemistry of Pharmaceutical Compounds (CPC) programme and Chair of Teaching and Learning in the School of Chemistry. He is a Principal Investigator (PI) in the School of Chemistry, Analytical and Biological Chemistry Research Facility (ABCRF), Future Pharmaceuticals and a Funded Investigator (FI) the Synthesis and Solid State Pharmaceutical Centre (SSPC), an SFI funded collaboration involving academia and industry. As of 2024, Dr. Collins has supervised 25 PhD students with 15 PhD students having completed and currently 10 PhD students in his research group. He has also supervised 4 MSc by Research students. The majority of the past students from his group are currently employed in the pharmaceutical industry in Ireland. There have been 11 Enterprise Partnership IRCSET/IRC PhD students in his research group (sponsored by GSK, Thermo, MSD, Pfizer, Lilly and Janssen), 10 Government of Ireland IRCSET/IRC sponsored PhD students, 3 SFI (SSPC) funded students and 1 DAFF (FIRM) funded student, with total grant income €2.88M; €1.46M over the period 2019-2024.
Research Interests
My research is focused mainly in the area of natural product synthesis and organic synthetic methodology with a particular emphasis on continuous processing and flow chemistry. The synthesis of small organic molecules that show biological activity against specific targets such as cancer, leukaemia, HIV etc. is a key overall theme of the group. I have supervised 25 PhD students with 15 graduated and currently 10 PhD students in the group. There have been 11 Enterprise Partnership IRC PhD students in my research group (sponsored by GSK, Thermo, MSD, Pfizer, Eli Lilly and Janssen), 10 Government of Ireland IRC sponsored PhD students, 3 SFI (SSPC) funded students and 1 DAFF (FIRM) funded PhD student. Over the past 5 years I have also supervised 20 Final Year Projects (17 Chemistry/CPC and 3 Pharmacy) and 3 UREKA SFI students and 4 Visiting Masters students from Poitiers University and Clermont-Ferrand, France. Recent areas of research in the group: 1. The synthesis and reactivity of 2-thio-3-chloroacrylamides (beta-chloroacrylamides). 2. New insights into the synthesis of novel alpha-diazocarbonyl compounds and applications to the synthesis of beta-lactone natural products. 3. Enzymatic transformations in stereoselective synthesis of compounds with potential antiviral activity 4. Synthesis and reactivity of novel alpha-diazosulfoxides: Formation of alpha-oxo sulfines as reactive intermediates. 5. Photochemical transformations in continuous flow 6. Exploring the potential of enantioselective copper bisoxazoline catalysts 7. Design and use of novel metal catalysts in organic synthesis including use of flow technology 8. New methods in Green Chemistry for Pharmaceutical processes. 9. Application of flow chemistry to processing involving hazardous intermediates 10. Development of tunable and scalable API processes through Advanced Process Control
Teaching Activities
Past 20 years Undergraduate teaching: CM1000 (now CM1201) Introduction to Chemistry – Organic Section on Functional Groups; CM2002/CM3030 Fundamentals of Organic Chemistry – Acidity and Basicity/Alkenes and Alkynes; CM2006/CM3029 Carbonyl Chemistry; CM3022 (now CM3001) Organic Synthesis, Intermediates and Heterocycles- Functional Groups and Reactive Intermediates; CM4022 (now CM4103) Pericyclic Reactions and Heterocycles; PF6200 Pharmaceutical Chemistry (MSc. Pharmaceutical Technology and Quality Systems); CM3004 Structure and Reactivity of Organic Compounds – Amino Acids and Peptides; CM4108 Advanced Pharmaceutical Chemistry; CM1912 An Introduction to Chemistry (Environmental Management) Course roles: Director BSc Chemistry of Pharmaceutical Compounds Programme (2017-present)4th Year CPC Coordinator (2017-Present) 2nd Year CPC Coordinator (2008-2017 and 2023-Present) 2nd Year Undergraduate Organic Chemistry Practical Coordinator (2007-Present) CM2002/CM3030 Module Coordinator (2007-Present) CM4103 Module Coordinator (2008-present) CM4204 Module Coordinator (2017-Present) CM4203 Module coordinator (2021-Present) CM4208 Module Coordinator (2021-Present) PF6200 Module Coordinator (2011-2021) Designed and developed the Pharmaceutical Analysis section of PF6200 Chemistry of Pharmaceutical compounds which is a 10 credit module in the MSc in Pharmaceutical Technology and Quality Systems, School of Pharmacy, UCC which is done through distance learning. I have been actively involved in the planning and development of the MSc course at all stages. Coordinator of the Postgraduate modules CM6101/7002/7003/7006 in Organic and Pharmaceutical Chemistry (2007-2018) and have been instrumental in the planning and set up of these modules and how the courses run over th
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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Exploring the Crystal Landscape of Mandelamide and Chiral Resolution via Cocrystallization
Huang, S., Fitzgerald, D., Koledoye, S. A., Collins, S. G., Maguire, A. R. & Lawrence, S. E., 1 Jan 2025, In: Crystal Growth and Design. 25, 1, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
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Formation of the E-isomer as an impurity in the optimized flow synthesis of a Z-α-thio-β-chloroacrylamide; E/Z photoisomerization in batch and flow, and solid state characterization of both isomers
Dennehy, O. C., Lynch, D., Khandavilli, U. B. R., Lawrence, S. E., Collins, S. G., Maguire, A. R. & Moynihan, H. A., 23 Jul 2025, In: Reaction Chemistry and Engineering. 10, 8, p. 1878-1886 9 p.Research output: Contribution to journal › Article › peer-review
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Intramolecular Photochemical C−H Insertions of α-Diazocarbonyl Compounds
O'Callaghan, K. S., Collins, S. G. & Maguire, A. R., 2 Dec 2024, In: European Journal of Organic Chemistry. 27, 45, e202400784.Research output: Contribution to journal › Review article › peer-review
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Selective Thermal Deprotection of N-Boc Protected Amines in Continuous Flow
Ryan, M. R., Lynch, D., Collins, S. G. & Maguire, A. R., 17 May 2024, In: Organic Process Research and Development. 28, 5, p. 1946-1963 18 p.Research output: Contribution to journal › Article › peer-review
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Susceptibility of the Different Oxygen-Sensing Probes to Interferences in Respirometric Bacterial Assays with Complex Media
Zanetti, C., Li, L., Gaspar, R. D. L., Santovito, E., Elisseeva, S., Collins, S. G., Maguire, A. R. & Papkovsky, D. B., Jan 2024, In: Sensors. 24, 1, 267.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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"The innovation never stops in Thermo Fisher — if you like a challenge, you'll thrive here!"
15/05/24
1 item of Media coverage
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UCC student nabs new Thermo Fisher prize for outstanding work in science studies
17/01/24
1 item of Media coverage
Press/Media