3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

Kung Ban; Sandra Duffy; Yelena Khakham; Vicky M. Avery; Andrew Hughes; Oliver Montagnat; Kasiram Katneni; Eileen Ryan; Jonathan B. Baell

doi:10.1016/j.bmcl.2010.08.065

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

Kung Ban
, Sandra Duffy
, Yelena Khakham
, Vicky M. Avery
, Andrew Hughes
, Oliver Montagnat
, Kasiram Katneni
, Eileen Ryan
, Jonathan B. Baell

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.

Original language	English
Pages (from-to)	6024-6029
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2010.08.065
Publication status	Published - Oct 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Malaria
Plasmodium falciparum
Triazenes

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10.1016/j.bmcl.2010.08.065

Cite this

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title = "3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity",

abstract = "We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.",

keywords = "Malaria, Plasmodium falciparum, Triazenes",

author = "Kung Ban and Sandra Duffy and Yelena Khakham and Avery, \{Vicky M.\} and Andrew Hughes and Oliver Montagnat and Kasiram Katneni and Eileen Ryan and Baell, \{Jonathan B.\}",

year = "2010",

month = oct,

doi = "10.1016/j.bmcl.2010.08.065",

language = "English",

volume = "20",

pages = "6024--6029",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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TY - JOUR

T1 - 3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

AU - Ban, Kung

AU - Duffy, Sandra

AU - Khakham, Yelena

AU - Avery, Vicky M.

AU - Hughes, Andrew

AU - Montagnat, Oliver

AU - Katneni, Kasiram

AU - Ryan, Eileen

AU - Baell, Jonathan B.

PY - 2010/10

Y1 - 2010/10

N2 - We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.

AB - We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.

KW - Malaria

KW - Plasmodium falciparum

KW - Triazenes

UR - https://www.scopus.com/pages/publications/77956928541

U2 - 10.1016/j.bmcl.2010.08.065

DO - 10.1016/j.bmcl.2010.08.065

M3 - Article

C2 - 20822904

AN - SCOPUS:77956928541

SN - 0960-894X

VL - 20

SP - 6024

EP - 6029

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 20

ER -

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

Abstract

UN SDGs

Keywords

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