409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis

Trevor Darby; Emma Smith; Aoife Quinlan; Grainne Hurley; David Clarke; Fergus Shanahan; Kenneth Nally; Silvia Melgar

doi:10.1016/s0016-5085(14)60317-6

409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis

Trevor Darby
, Emma Smith
, Aoife Quinlan
, Grainne Hurley
, David Clarke
, Fergus Shanahan
, Kenneth Nally
, Silvia Melgar

Research output: Contribution to journal › Article › peer-review

Abstract

This two-stage study (cross-sectional and case-control) assessed the effects of delayed second dose HB vaccination on the risk of developing chronic HBV infection in infants born to chronically HBV infected mothers. 521 infants enrolled received the first vaccination by the end of the day after birth, without HBIG. 15 of these infants were chronically HBV infected. In the case-control comparison, controlling for HBeAg in the mother, the risk of an infant becoming chronically infected was 3.74 times (95% CI = 0.97-14.39) higher if the interval between the first and the second doses exceeded 10 weeks. This finding suggests it is important that immunization programs ensure timely second dose vaccination to infants born to mothers with chronic HBV infection. Nevertheless, due to the small sample size, these findings should be verified by larger studies. 2009 Elsevier Ltd. All rights reserved.

Original language	English (Ireland)
Pages (from-to)	S-88
Journal	Gastroenterology
Volume	146
Issue number	5
DOIs	https://doi.org/10.1016/s0016-5085(14)60317-6
Publication status	Published - May 2014

Access to Document

10.1016/s0016-5085(14)60317-6

Cite this

Darby, T., Smith, E., Quinlan, A., Hurley, G., Clarke, D., Shanahan, F., Nally, K., & Melgar, S. (2014). 409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis. Gastroenterology, 146(5), S-88. https://doi.org/10.1016/s0016-5085(14)60317-6

@article{df9df16c57fe4898bc2fd6981999bedd,

title = "409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis",

abstract = "This two-stage study (cross-sectional and case-control) assessed the effects of delayed second dose HB vaccination on the risk of developing chronic HBV infection in infants born to chronically HBV infected mothers. 521 infants enrolled received the first vaccination by the end of the day after birth, without HBIG. 15 of these infants were chronically HBV infected. In the case-control comparison, controlling for HBeAg in the mother, the risk of an infant becoming chronically infected was 3.74 times (95\% CI = 0.97-14.39) higher if the interval between the first and the second doses exceeded 10 weeks. This finding suggests it is important that immunization programs ensure timely second dose vaccination to infants born to mothers with chronic HBV infection. Nevertheless, due to the small sample size, these findings should be verified by larger studies. 2009 Elsevier Ltd. All rights reserved.",

author = "Trevor Darby and Emma Smith and Aoife Quinlan and Grainne Hurley and David Clarke and Fergus Shanahan and Kenneth Nally and Silvia Melgar",

year = "2014",

month = may,

doi = "10.1016/s0016-5085(14)60317-6",

language = "English (Ireland)",

volume = "146",

pages = "S--88",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders",

number = "5",

}

Darby, T, Smith, E, Quinlan, A, Hurley, G, Clarke, D, Shanahan, F, Nally, K & Melgar, S 2014, '409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis', Gastroenterology, vol. 146, no. 5, pp. S-88. https://doi.org/10.1016/s0016-5085(14)60317-6

TY - JOUR

T1 - 409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis

AU - Darby, Trevor

AU - Smith, Emma

AU - Quinlan, Aoife

AU - Hurley, Grainne

AU - Clarke, David

AU - Shanahan, Fergus

AU - Nally, Kenneth

AU - Melgar, Silvia

PY - 2014/5

Y1 - 2014/5

N2 - This two-stage study (cross-sectional and case-control) assessed the effects of delayed second dose HB vaccination on the risk of developing chronic HBV infection in infants born to chronically HBV infected mothers. 521 infants enrolled received the first vaccination by the end of the day after birth, without HBIG. 15 of these infants were chronically HBV infected. In the case-control comparison, controlling for HBeAg in the mother, the risk of an infant becoming chronically infected was 3.74 times (95% CI = 0.97-14.39) higher if the interval between the first and the second doses exceeded 10 weeks. This finding suggests it is important that immunization programs ensure timely second dose vaccination to infants born to mothers with chronic HBV infection. Nevertheless, due to the small sample size, these findings should be verified by larger studies. 2009 Elsevier Ltd. All rights reserved.

AB - This two-stage study (cross-sectional and case-control) assessed the effects of delayed second dose HB vaccination on the risk of developing chronic HBV infection in infants born to chronically HBV infected mothers. 521 infants enrolled received the first vaccination by the end of the day after birth, without HBIG. 15 of these infants were chronically HBV infected. In the case-control comparison, controlling for HBeAg in the mother, the risk of an infant becoming chronically infected was 3.74 times (95% CI = 0.97-14.39) higher if the interval between the first and the second doses exceeded 10 weeks. This finding suggests it is important that immunization programs ensure timely second dose vaccination to infants born to mothers with chronic HBV infection. Nevertheless, due to the small sample size, these findings should be verified by larger studies. 2009 Elsevier Ltd. All rights reserved.

UR - https://www.mendeley.com/catalogue/ec9051fb-5240-3576-a09e-b9972ad1876a/

U2 - 10.1016/s0016-5085(14)60317-6

DO - 10.1016/s0016-5085(14)60317-6

M3 - Article

SN - 0016-5085

VL - 146

SP - S-88

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -

409 The Colonic Adherent-Invasive Escherichia coli Strain HM605 Induces Anti-Apoptotic Responses in Intestinal Epithelial Cells, Reduces Barrier Integrity and Worsens Experimental Colitis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this