A comparison of the puncturing properties of Gelatin and hypromellose capsules for use in dry powder inhalers

J. C. Birchall; B. E. Jones; A. Morrissey; B. E. Jones

doi:10.1080/03639040801928903

A comparison of the puncturing properties of Gelatin and hypromellose capsules for use in dry powder inhalers

J. C. Birchall
, B. E. Jones
, A. Morrissey
, B. E. Jones

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Research output: Contribution to journal › Article › peer-review

Abstract

This study investigates capsule puncture in dry powder inhalers. Gelatin and hydroxypropylmethyl cellulose (HPMC) capsules (stored at 11 and 33% relative humidities) were punctured using a pin from a Foradil® inhaler, with insertion force measurement via an Instron tester. In HPMC capsules, the force after capsule puncture reduced by half and then increased to a second maximum as the pin shaft entered the hole. In gelatin capsules, the postpuncture force reduced to zero, indicating shell flaps losing contact with the pin. At lower moisture contents, both capsules were less flexible. This provides a tool to measure the shell properties of inhalation capsules.

Original language	English
Pages (from-to)	870-876
Number of pages	7
Journal	Drug Development and Industrial Pharmacy
Volume	34
Issue number	8
DOIs	https://doi.org/10.1080/03639040801928903
Publication status	Published - Aug 2008

Keywords

Capsule
Dry powder inhaler
Gelatin
HPMC
Puncture

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10.1080/03639040801928903

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title = "A comparison of the puncturing properties of Gelatin and hypromellose capsules for use in dry powder inhalers",

abstract = "This study investigates capsule puncture in dry powder inhalers. Gelatin and hydroxypropylmethyl cellulose (HPMC) capsules (stored at 11 and 33\% relative humidities) were punctured using a pin from a Foradil{\textregistered} inhaler, with insertion force measurement via an Instron tester. In HPMC capsules, the force after capsule puncture reduced by half and then increased to a second maximum as the pin shaft entered the hole. In gelatin capsules, the postpuncture force reduced to zero, indicating shell flaps losing contact with the pin. At lower moisture contents, both capsules were less flexible. This provides a tool to measure the shell properties of inhalation capsules.",

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AU - Morrissey, A.

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AB - This study investigates capsule puncture in dry powder inhalers. Gelatin and hydroxypropylmethyl cellulose (HPMC) capsules (stored at 11 and 33% relative humidities) were punctured using a pin from a Foradil® inhaler, with insertion force measurement via an Instron tester. In HPMC capsules, the force after capsule puncture reduced by half and then increased to a second maximum as the pin shaft entered the hole. In gelatin capsules, the postpuncture force reduced to zero, indicating shell flaps losing contact with the pin. At lower moisture contents, both capsules were less flexible. This provides a tool to measure the shell properties of inhalation capsules.

KW - Capsule

KW - Dry powder inhaler

KW - Gelatin

KW - HPMC

KW - Puncture

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JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

IS - 8

ER -

A comparison of the puncturing properties of Gelatin and hypromellose capsules for use in dry powder inhalers

Abstract

Keywords

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