A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone

John F. Atkins; Gary Loughran; Pavel V. Baranov

doi:10.1016/j.molcel.2017.01.002

A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone

John F. Atkins
, Gary Loughran
, Pavel V. Baranov

School of Biochemistry and Cell Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.

Original language	English
Pages (from-to)	203-204
Number of pages	2
Journal	Molecular Cell
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2017.01.002
Publication status	Published - 19 Jan 2017

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title = "A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone",

abstract = "In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.",

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note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

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T1 - A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone

AU - Atkins, John F.

AU - Loughran, Gary

AU - Baranov, Pavel V.

PY - 2017/1/19

Y1 - 2017/1/19

N2 - In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.

AB - In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.

UR - https://www.scopus.com/pages/publications/85010281204

U2 - 10.1016/j.molcel.2017.01.002

DO - 10.1016/j.molcel.2017.01.002

M3 - Short survey

C2 - 28107645

AN - SCOPUS:85010281204

SN - 1097-2765

VL - 65

SP - 203

EP - 204

JO - Molecular Cell

JF - Molecular Cell

IS - 2

ER -

A [Cu]rious Ribosomal Profiling Pattern Leads to the Discovery of Ribosomal Frameshifting in the Synthesis of a Copper Chaperone

Abstract

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