Abstract
The operating performance of deionized and water for injection (DI/WFI) distribution systems can be difficult to analyse due to the highly variable demand that is drawn from these systems, a situation compounded by schedule uncertainties. This paper presents a fuzzy logic (FL) model of a typical DI/WFI system simulating schedule uncertainties in the opening and closing events of the offtake valves based on operator behaviour, e.g. tiredness of the operators. The model utilises discrete-event simulation to calculate the demand profile of the distribution system and a continuous simulation to compute the variation of the level in the storage tank. It is shown that the FL model may be useful in the design of new DI/WFI systems if little historical data are available.
| Original language | English |
|---|---|
| Pages (from-to) | 125-141 |
| Number of pages | 17 |
| Journal | Journal of Pharmaceutical Innovation |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2011 |
Keywords
- Capacity extension
- DI
- Fuzzy logic
- High-purity water
- Uncertainty
- WFI