TY - CHAP
T1 - A method to determine the margin of safety for microneedles arrays
AU - Forvi, E.
AU - Soncini, M.
AU - Bedoni, M.
AU - Rizzo, F.
AU - Casella, M.
AU - O'Mahony, C.
AU - Gramatica, F.
PY - 2010
Y1 - 2010
N2 - Microneedles, before being used for biomedical applications, have to satisfy biological and technical specifications, in particular they must guarantee a sufficient strength during exercise. Although studies on the mechanical characterization on single microneedles are reported in literature, microneedles must be arranged in matrices to be used in real biomedical applications. For these reasons, it is necessary to define a margin of safety for complete arrays of microneedles. In this study forces required to pierce human skin, by means of piercing tests, and maximum forces which arrays can withstand without breaking, through compressive tests, are carried out to determine a preliminary margin of safety for microneedles arrays.
AB - Microneedles, before being used for biomedical applications, have to satisfy biological and technical specifications, in particular they must guarantee a sufficient strength during exercise. Although studies on the mechanical characterization on single microneedles are reported in literature, microneedles must be arranged in matrices to be used in real biomedical applications. For these reasons, it is necessary to define a margin of safety for complete arrays of microneedles. In this study forces required to pierce human skin, by means of piercing tests, and maximum forces which arrays can withstand without breaking, through compressive tests, are carried out to determine a preliminary margin of safety for microneedles arrays.
KW - Array
KW - Mechanical characterization
KW - Microneedles
UR - https://www.scopus.com/pages/publications/79959856445
M3 - Chapter
AN - SCOPUS:79959856445
SN - 9789881821072
T3 - WCE 2010 - World Congress on Engineering 2010
SP - 1550
EP - 1554
BT - WCE 2010 - World Congress on Engineering 2010
T2 - World Congress on Engineering 2010, WCE 2010
Y2 - 30 June 2010 through 2 July 2010
ER -