A Microbial Drugstore for Motility

John F. Cryan; Gerard Clarke; Timothy G. Dinan; Harriet Schellekens

doi:10.1016/j.chom.2018.05.020

A Microbial Drugstore for Motility

Research output: Contribution to journal › Short survey › peer-review

Abstract

While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility. While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.

Original language	English
Pages (from-to)	691-692
Number of pages	2
Journal	Cell Host and Microbe
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2018.05.020
Publication status	Published - 13 Jun 2018

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10.1016/j.chom.2018.05.020

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title = "A Microbial Drugstore for Motility",

abstract = "While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host \& Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility. While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host \& Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.",

author = "Cryan, \{John F.\} and Gerard Clarke and Dinan, \{Timothy G.\} and Harriet Schellekens",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

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T1 - A Microbial Drugstore for Motility

AU - Cryan, John F.

AU - Clarke, Gerard

AU - Dinan, Timothy G.

AU - Schellekens, Harriet

PY - 2018/6/13

Y1 - 2018/6/13

N2 - While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility. While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.

AB - While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility. While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.

UR - https://www.scopus.com/pages/publications/85048148179

U2 - 10.1016/j.chom.2018.05.020

DO - 10.1016/j.chom.2018.05.020

M3 - Short survey

C2 - 29902430

AN - SCOPUS:85048148179

SN - 1931-3128

VL - 23

SP - 691

EP - 692

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

A Microbial Drugstore for Motility

Abstract

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