TY - JOUR
T1 - A Microbial Drugstore for Motility
AU - Cryan, John F.
AU - Clarke, Gerard
AU - Dinan, Timothy G.
AU - Schellekens, Harriet
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/6/13
Y1 - 2018/6/13
N2 - While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility. While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.
AB - While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility. While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.
UR - https://www.scopus.com/pages/publications/85048148179
U2 - 10.1016/j.chom.2018.05.020
DO - 10.1016/j.chom.2018.05.020
M3 - Short survey
C2 - 29902430
AN - SCOPUS:85048148179
SN - 1931-3128
VL - 23
SP - 691
EP - 692
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 6
ER -