TY - JOUR
T1 - A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model
AU - Marron, Lynda
AU - Emerson, Nathan
AU - Gahan, Cormac G.M.
AU - Hill, Colin
PY - 1997/12
Y1 - 1997/12
N2 - Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.
AB - Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.
UR - https://www.scopus.com/pages/publications/0030734260
U2 - 10.1128/aem.63.12.4945-4947.1997
DO - 10.1128/aem.63.12.4945-4947.1997
M3 - Article
C2 - 9406415
AN - SCOPUS:0030734260
SN - 0099-2240
VL - 63
SP - 4945
EP - 4947
JO - Applied and Environmental Microbiology
JF - Applied and Environmental Microbiology
IS - 12
ER -