A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates

Nuala M. Maguire; Alan Ford; Sarah L. Clarke; Kevin S. Eccles; Simon E. Lawrence; Maude Brossat; Thomas S. Moody; Anita R. Maguire

doi:10.1016/j.tetasy.2011.11.022

A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates

Nuala M. Maguire
, Alan Ford
, Sarah L. Clarke
, Kevin S. Eccles
, Simon E. Lawrence
, Maude Brossat
, Thomas S. Moody
, Anita R. Maguire

Almac Group

Research output: Contribution to journal › Article › peer-review

Abstract

The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates.

Original language	English
Pages (from-to)	2144-2150
Number of pages	7
Journal	Tetrahedron Asymmetry
Volume	22
Issue number	24
DOIs	https://doi.org/10.1016/j.tetasy.2011.11.022
Publication status	Published - 31 Dec 2011

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10.1016/j.tetasy.2011.11.022

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title = "A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates",

abstract = "The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates.",

author = "Maguire, \{Nuala M.\} and Alan Ford and Clarke, \{Sarah L.\} and Eccles, \{Kevin S.\} and Lawrence, \{Simon E.\} and Maude Brossat and Moody, \{Thomas S.\} and Maguire, \{Anita R.\}",

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AU - Maguire, Nuala M.

AU - Ford, Alan

AU - Clarke, Sarah L.

AU - Eccles, Kevin S.

AU - Lawrence, Simon E.

AU - Brossat, Maude

AU - Moody, Thomas S.

AU - Maguire, Anita R.

PY - 2011/12/31

Y1 - 2011/12/31

N2 - The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates.

AB - The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates.

UR - https://www.scopus.com/pages/publications/84856368325

U2 - 10.1016/j.tetasy.2011.11.022

DO - 10.1016/j.tetasy.2011.11.022

M3 - Article

AN - SCOPUS:84856368325

SN - 0957-4166

VL - 22

SP - 2144

EP - 2150

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 24

ER -

A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates

Abstract

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