A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications

K. Rahme; G. Minassian; E. Ghanem; M. Nakhl; R. El Hage; E. Souaid; J. D. Holmes

A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications

K. Rahme
, G. Minassian
, E. Ghanem
, M. Nakhl
, R. El Hage
, E. Souaid
, J. D. Holmes

School of Chemistry

Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review

Abstract

In this study Silver (Ag) and Gold (Au) nanoparticles (NPs) of different surface charges (positively charged, negatively charged, or nearly neutral) and sizes were obtained using ascorbic acid as a reducing agent and multiple polymers such as Chitosan (Chit), Poly-L-Lysine (PLL), Polyvinyl alcohol (PVA), Polyethylene glycol (PEG) or sodium citrate as stabilizing ligands. The obtained NPs were characterized using UV-visible spectroscopy (UV-vis), Dynamic Light Scattering (DLS), and Zeta Potential (Q measurements. On the other hand, AuNPs with different coating (PLL, PVA and PEG) and charges were tested on whole human blood samples, specifically on neutrophils using a Neutrophil Function Test (NFT). Our results demonstrated that AuNPs-PVA with a slight negative charge (C = -15 mV) and PEgylated AuNPs-PLL (AuNPs-PLL-PEG) with a slight positive charge (ζ = + 9 mV) were found to be the least detected by neutrophils making them suitable for biomedical applications.

Original language	English
Title of host publication	TechConnect Briefs 2018 - Advanced Materials
Editors	Matthew Laudon, Fiona Case, Fiona Case, Bart Romanowicz
Publisher	TechConnect
Pages	87-90
Number of pages	4
ISBN (Electronic)	9780998878225
Publication status	Published - 2018
Event	11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference - Anaheim, United States Duration: 13 May 2018 → 16 May 2018

Publication series

Name	TechConnect Briefs 2018 - Advanced Materials
Volume	1

Conference

Conference	11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference
Country/Territory	United States
City	Anaheim
Period	13/05/18 → 16/05/18

Keywords

Cancer
Cytotoxixity
Nanoparticles
Neutrophils
Polymers

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Rahme, K., Minassian, G., Ghanem, E., Nakhl, M., El Hage, R., Souaid, E., & Holmes, J. D. (2018). A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications. In M. Laudon, F. Case, F. Case, & B. Romanowicz (Eds.), TechConnect Briefs 2018 - Advanced Materials (pp. 87-90). (TechConnect Briefs 2018 - Advanced Materials; Vol. 1). TechConnect.

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title = "A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications",

abstract = "In this study Silver (Ag) and Gold (Au) nanoparticles (NPs) of different surface charges (positively charged, negatively charged, or nearly neutral) and sizes were obtained using ascorbic acid as a reducing agent and multiple polymers such as Chitosan (Chit), Poly-L-Lysine (PLL), Polyvinyl alcohol (PVA), Polyethylene glycol (PEG) or sodium citrate as stabilizing ligands. The obtained NPs were characterized using UV-visible spectroscopy (UV-vis), Dynamic Light Scattering (DLS), and Zeta Potential (Q measurements. On the other hand, AuNPs with different coating (PLL, PVA and PEG) and charges were tested on whole human blood samples, specifically on neutrophils using a Neutrophil Function Test (NFT). Our results demonstrated that AuNPs-PVA with a slight negative charge (C = -15 mV) and PEgylated AuNPs-PLL (AuNPs-PLL-PEG) with a slight positive charge (ζ = + 9 mV) were found to be the least detected by neutrophils making them suitable for biomedical applications.",

keywords = "Cancer, Cytotoxixity, Nanoparticles, Neutrophils, Polymers",

author = "K. Rahme and G. Minassian and E. Ghanem and M. Nakhl and \{El Hage\}, R. and E. Souaid and Holmes, \{J. D.\}",

note = "Publisher Copyright: {\textcopyright} 2018 TechConnect. All rights reserved.; 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference ; Conference date: 13-05-2018 Through 16-05-2018",

year = "2018",

language = "English",

series = "TechConnect Briefs 2018 - Advanced Materials",

publisher = "TechConnect",

pages = "87--90",

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}

Rahme, K, Minassian, G, Ghanem, E, Nakhl, M, El Hage, R, Souaid, E & Holmes, JD 2018, A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications. in M Laudon, F Case, F Case & B Romanowicz (eds), TechConnect Briefs 2018 - Advanced Materials. TechConnect Briefs 2018 - Advanced Materials, vol. 1, TechConnect, pp. 87-90, 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference, Anaheim, United States, 13/05/18.

A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications. / Rahme, K.; Minassian, G.; Ghanem, E. et al.
TechConnect Briefs 2018 - Advanced Materials. ed. / Matthew Laudon; Fiona Case; Fiona Case; Bart Romanowicz. TechConnect, 2018. p. 87-90 (TechConnect Briefs 2018 - Advanced Materials; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedings › Chapter › peer-review

TY - CHAP

T1 - A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications

AU - Rahme, K.

AU - Minassian, G.

AU - Ghanem, E.

AU - Nakhl, M.

AU - El Hage, R.

AU - Souaid, E.

AU - Holmes, J. D.

PY - 2018

Y1 - 2018

N2 - In this study Silver (Ag) and Gold (Au) nanoparticles (NPs) of different surface charges (positively charged, negatively charged, or nearly neutral) and sizes were obtained using ascorbic acid as a reducing agent and multiple polymers such as Chitosan (Chit), Poly-L-Lysine (PLL), Polyvinyl alcohol (PVA), Polyethylene glycol (PEG) or sodium citrate as stabilizing ligands. The obtained NPs were characterized using UV-visible spectroscopy (UV-vis), Dynamic Light Scattering (DLS), and Zeta Potential (Q measurements. On the other hand, AuNPs with different coating (PLL, PVA and PEG) and charges were tested on whole human blood samples, specifically on neutrophils using a Neutrophil Function Test (NFT). Our results demonstrated that AuNPs-PVA with a slight negative charge (C = -15 mV) and PEgylated AuNPs-PLL (AuNPs-PLL-PEG) with a slight positive charge (ζ = + 9 mV) were found to be the least detected by neutrophils making them suitable for biomedical applications.

AB - In this study Silver (Ag) and Gold (Au) nanoparticles (NPs) of different surface charges (positively charged, negatively charged, or nearly neutral) and sizes were obtained using ascorbic acid as a reducing agent and multiple polymers such as Chitosan (Chit), Poly-L-Lysine (PLL), Polyvinyl alcohol (PVA), Polyethylene glycol (PEG) or sodium citrate as stabilizing ligands. The obtained NPs were characterized using UV-visible spectroscopy (UV-vis), Dynamic Light Scattering (DLS), and Zeta Potential (Q measurements. On the other hand, AuNPs with different coating (PLL, PVA and PEG) and charges were tested on whole human blood samples, specifically on neutrophils using a Neutrophil Function Test (NFT). Our results demonstrated that AuNPs-PVA with a slight negative charge (C = -15 mV) and PEgylated AuNPs-PLL (AuNPs-PLL-PEG) with a slight positive charge (ζ = + 9 mV) were found to be the least detected by neutrophils making them suitable for biomedical applications.

KW - Cancer

KW - Cytotoxixity

KW - Nanoparticles

KW - Neutrophils

KW - Polymers

UR - https://www.scopus.com/pages/publications/85050817559

M3 - Chapter

AN - SCOPUS:85050817559

T3 - TechConnect Briefs 2018 - Advanced Materials

SP - 87

EP - 90

BT - TechConnect Briefs 2018 - Advanced Materials

A2 - Laudon, Matthew

A2 - Case, Fiona

A2 - Romanowicz, Bart

PB - TechConnect

T2 - 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo,the 2018 SBIR/STTR Spring Innovation Conference, and the Defense TechConnect DTC Spring Conference

Y2 - 13 May 2018 through 16 May 2018

ER -

A simple synthesis of polymer coated gold and silver nanoparticles in water for potential use in biomedical applications

Abstract

Publication series

Conference

Keywords

UN SDGs

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