AB059. SOH23ABS_201. Differential gene expression of immune related genes in breast cancer tumour and normal adjacent to tumour tissues

Carolyn Cullinane; James Byrne; Mark Corrigan; Roisin Connolly; Cathriona Foley; Henry Paul Redmond

doi:10.21037/map-23-ab059

AB059. SOH23ABS_201. Differential gene expression of immune related genes in breast cancer tumour and normal adjacent to tumour tissues

Carolyn Cullinane
, James Byrne
, Mark Corrigan
, Roisin Connolly
, Cathriona Foley
, Henry Paul Redmond

School of Medicine

Cork University Hospital

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

The immune response plays a significant role in the post-operative breast tissue environment of breast cancer (BC) patients. The extent of post-operative inflammation and immunosuppression is associated with BC recurrence. Determining the baseline immune profile of normal adjacent to tumour (NAT) tissue may provide an insight into patient outcomes. We aimed to compare the transcriptome of BC tumour and NAT to determine the differential gene expression of immune related genes, pathways and patient outcome.

Original language	English
Journal	Mesentery and Peritoneum
DOIs	https://doi.org/10.21037/map-23-ab059
Publication status	Published - 31 May 2023
Event	The Sylvester O'Halloran Perioperative Symposium 2023 - Limerick, Ireland Duration: 3 Mar 2023 → 5 Mar 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gene
Breast cancer
Immune system
Biology
Cancer
Gene expression
Cancer research
Pathology
Medicine
Genetics

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10.21037/map-23-ab059Licence: CC BY-NC-ND

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title = "AB059. SOH23ABS\_201. Differential gene expression of immune related genes in breast cancer tumour and normal adjacent to tumour tissues",

abstract = "The immune response plays a significant role in the post-operative breast tissue environment of breast cancer (BC) patients. The extent of post-operative inflammation and immunosuppression is associated with BC recurrence. Determining the baseline immune profile of normal adjacent to tumour (NAT) tissue may provide an insight into patient outcomes. We aimed to compare the transcriptome of BC tumour and NAT to determine the differential gene expression of immune related genes, pathways and patient outcome.",

keywords = "Gene, Breast cancer, Immune system, Biology, Cancer, Gene expression, Cancer research, Pathology, Medicine, Genetics",

author = "Carolyn Cullinane and James Byrne and Mark Corrigan and Roisin Connolly and Cathriona Foley and Redmond, \{Henry Paul\}",

year = "2023",

month = may,

day = "31",

doi = "10.21037/map-23-ab059",

language = "English",

journal = "Mesentery and Peritoneum",

issn = "2616-2725",

note = "The Sylvester O'Halloran Perioperative Symposium 2023 ; Conference date: 03-03-2023 Through 05-03-2023",

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TY - JOUR

T1 - AB059. SOH23ABS_201. Differential gene expression of immune related genes in breast cancer tumour and normal adjacent to tumour tissues

AU - Cullinane, Carolyn

AU - Byrne, James

AU - Corrigan, Mark

AU - Connolly, Roisin

AU - Foley, Cathriona

AU - Redmond, Henry Paul

PY - 2023/5/31

Y1 - 2023/5/31

N2 - The immune response plays a significant role in the post-operative breast tissue environment of breast cancer (BC) patients. The extent of post-operative inflammation and immunosuppression is associated with BC recurrence. Determining the baseline immune profile of normal adjacent to tumour (NAT) tissue may provide an insight into patient outcomes. We aimed to compare the transcriptome of BC tumour and NAT to determine the differential gene expression of immune related genes, pathways and patient outcome.

AB - The immune response plays a significant role in the post-operative breast tissue environment of breast cancer (BC) patients. The extent of post-operative inflammation and immunosuppression is associated with BC recurrence. Determining the baseline immune profile of normal adjacent to tumour (NAT) tissue may provide an insight into patient outcomes. We aimed to compare the transcriptome of BC tumour and NAT to determine the differential gene expression of immune related genes, pathways and patient outcome.

KW - Gene

KW - Breast cancer

KW - Immune system

KW - Biology

KW - Cancer

KW - Gene expression

KW - Cancer research

KW - Pathology

KW - Medicine

KW - Genetics

UR - https://openalex.org/W4378902704

U2 - 10.21037/map-23-ab059

DO - 10.21037/map-23-ab059

M3 - Meeting abstract

SN - 2616-2725

JO - Mesentery and Peritoneum

JF - Mesentery and Peritoneum

T2 - The Sylvester O'Halloran Perioperative Symposium 2023

Y2 - 3 March 2023 through 5 March 2023

ER -

AB059. SOH23ABS_201. Differential gene expression of immune related genes in breast cancer tumour and normal adjacent to tumour tissues

Abstract

UN SDGs

Keywords

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