Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancer

Astrid Zedlitz Johansen; Hannes Linder; Cecilie Ølvang Madsen; Kevin James Baker; Klaire Yixin Fjæstad; Shawez Khan; Nadia Kolvig Czajkowski; Christian Thygesen; Majken Siersbæk; Frederik Otzen Bagger; Marco Donia; Lars Henning  Engelholm; Lars  Grøntved; Daniel Hargbøl Madsen

Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancer

Astrid Zedlitz Johansen
, Hannes Linder
, Cecilie Ølvang Madsen
, Kevin James Baker
, Klaire Yixin Fjæstad
, Shawez Khan
, Nadia Kolvig Czajkowski
, Christian Thygesen
, Majken Siersbæk
, Frederik Otzen Bagger
, Marco Donia
, Lars Henning Engelholm
, Lars Grøntved
, Daniel Hargbøl Madsen

School of Medicine

Copenhagen University Hospital
University of Southern Denmark
University of Copenhagen

Research output: Contribution to journal › Article

Original language	English (Ireland)
Journal	bioRxiv
Publication status	Published - 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@article{6fad6a94616947b6bbecafa409c3a933,

title = "Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancer",

author = "Johansen, \{Astrid Zedlitz\} and Hannes Linder and Madsen, \{Cecilie {\O}lvang\} and Baker, \{Kevin James\} and Fj{\ae}stad, \{Klaire Yixin\} and Shawez Khan and Czajkowski, \{Nadia Kolvig\} and Christian Thygesen and Majken Siersb{\ae}k and Bagger, \{Frederik Otzen\} and Marco Donia and Engelholm, \{Lars Henning\} and Lars Gr{\o}ntved and Madsen, \{Daniel Hargb{\o}l\}",

year = "2026",

language = "English (Ireland)",

journal = "bioRxiv",

issn = "2692-8205",

publisher = "Cold Spring Harbor Laboratory Press",

}

TY - JOUR

T1 - Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancer

AU - Johansen, Astrid Zedlitz

AU - Linder, Hannes

AU - Madsen, Cecilie Ølvang

AU - Baker, Kevin James

AU - Fjæstad, Klaire Yixin

AU - Khan, Shawez

AU - Czajkowski, Nadia Kolvig

AU - Thygesen, Christian

AU - Siersbæk, Majken

AU - Bagger, Frederik Otzen

AU - Donia, Marco

AU - Engelholm, Lars Henning

AU - Grøntved, Lars

AU - Madsen , Daniel Hargbøl

PY - 2026

Y1 - 2026

M3 - Article

SN - 2692-8205

JO - bioRxiv

JF - bioRxiv

ER -