Alterations of the retinoic acid receptor α (RARα) gene in myeloid and lymphoid malignancies

Antonio Parrado; Robert West; Denise Jordan; Christian Bastard; Sharon McKenna; Jack A. Whittaker; Paul Bentley; Denise White; Christine Chomienne; Rose Ann Padua

doi:10.1046/j.1365-2141.1999.01240.x

Alterations of the retinoic acid receptor α (RARα) gene in myeloid and lymphoid malignancies

Antonio Parrado
, Robert West
, Denise Jordan
, Christian Bastard
, Sharon McKenna
, Jack A. Whittaker
, Paul Bentley
, Denise White
, Christine Chomienne
, Rose Ann Padua

Université Paris Cité
Cardiff University
Etablissement Tranfus. S./G.H.H.N.
Cardiff & Vale University Health Board

Research output: Contribution to journal › Article › peer-review

Abstract

The retinoic acid receptor α (RARα) protein plays a central role in myeloid differentiation, and chromosomal translocations disrupting the RARα gene are implicated in the development of acute myeloid leukaemia (AML). To identify haemopoietic malignant disorders which may also be linked to RARα abnormalities, Southern blot analysis was performed in DNA from 153 patients with haematological malignancies other than AML FAB type M3 using RARα CDNA probes. Alterations of RARα were detected in 1/42 myelodysplastic syndromes (MDS), 2/24 AML, 3/47 B-chronic lymphocytic leukaemias (B-CLL), 0/40 lymphomas and 0/60 normal individuals. These data strongly suggest that alterations of RARα might predispose for myeloid and lymphoid disorders.

Original language	English
Pages (from-to)	738-741
Number of pages	4
Journal	British Journal of Haematology
Volume	104
Issue number	4
DOIs	https://doi.org/10.1046/j.1365-2141.1999.01240.x
Publication status	Published - 1999
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute myeloid leukaemia
B-chronic lymphocytic leukaemia
Myelodysplastic syndromes
Retinoic acid receptor alpha

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10.1046/j.1365-2141.1999.01240.x

Cite this

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title = "Alterations of the retinoic acid receptor α (RARα) gene in myeloid and lymphoid malignancies",

abstract = "The retinoic acid receptor α (RARα) protein plays a central role in myeloid differentiation, and chromosomal translocations disrupting the RARα gene are implicated in the development of acute myeloid leukaemia (AML). To identify haemopoietic malignant disorders which may also be linked to RARα abnormalities, Southern blot analysis was performed in DNA from 153 patients with haematological malignancies other than AML FAB type M3 using RARα CDNA probes. Alterations of RARα were detected in 1/42 myelodysplastic syndromes (MDS), 2/24 AML, 3/47 B-chronic lymphocytic leukaemias (B-CLL), 0/40 lymphomas and 0/60 normal individuals. These data strongly suggest that alterations of RARα might predispose for myeloid and lymphoid disorders.",

keywords = "Acute myeloid leukaemia, B-chronic lymphocytic leukaemia, Myelodysplastic syndromes, Retinoic acid receptor alpha",

author = "Antonio Parrado and Robert West and Denise Jordan and Christian Bastard and Sharon McKenna and Whittaker, \{Jack A.\} and Paul Bentley and Denise White and Christine Chomienne and Padua, \{Rose Ann\}",

year = "1999",

doi = "10.1046/j.1365-2141.1999.01240.x",

language = "English",

volume = "104",

pages = "738--741",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc",

number = "4",

}

TY - JOUR

T1 - Alterations of the retinoic acid receptor α (RARα) gene in myeloid and lymphoid malignancies

AU - Parrado, Antonio

AU - West, Robert

AU - Jordan, Denise

AU - Bastard, Christian

AU - McKenna, Sharon

AU - Whittaker, Jack A.

AU - Bentley, Paul

AU - White, Denise

AU - Chomienne, Christine

AU - Padua, Rose Ann

PY - 1999

Y1 - 1999

N2 - The retinoic acid receptor α (RARα) protein plays a central role in myeloid differentiation, and chromosomal translocations disrupting the RARα gene are implicated in the development of acute myeloid leukaemia (AML). To identify haemopoietic malignant disorders which may also be linked to RARα abnormalities, Southern blot analysis was performed in DNA from 153 patients with haematological malignancies other than AML FAB type M3 using RARα CDNA probes. Alterations of RARα were detected in 1/42 myelodysplastic syndromes (MDS), 2/24 AML, 3/47 B-chronic lymphocytic leukaemias (B-CLL), 0/40 lymphomas and 0/60 normal individuals. These data strongly suggest that alterations of RARα might predispose for myeloid and lymphoid disorders.

AB - The retinoic acid receptor α (RARα) protein plays a central role in myeloid differentiation, and chromosomal translocations disrupting the RARα gene are implicated in the development of acute myeloid leukaemia (AML). To identify haemopoietic malignant disorders which may also be linked to RARα abnormalities, Southern blot analysis was performed in DNA from 153 patients with haematological malignancies other than AML FAB type M3 using RARα CDNA probes. Alterations of RARα were detected in 1/42 myelodysplastic syndromes (MDS), 2/24 AML, 3/47 B-chronic lymphocytic leukaemias (B-CLL), 0/40 lymphomas and 0/60 normal individuals. These data strongly suggest that alterations of RARα might predispose for myeloid and lymphoid disorders.

KW - Acute myeloid leukaemia

KW - B-chronic lymphocytic leukaemia

KW - Myelodysplastic syndromes

KW - Retinoic acid receptor alpha

UR - https://www.scopus.com/pages/publications/0033003845

U2 - 10.1046/j.1365-2141.1999.01240.x

DO - 10.1046/j.1365-2141.1999.01240.x

M3 - Article

C2 - 10192433

AN - SCOPUS:0033003845

SN - 0007-1048

VL - 104

SP - 738

EP - 741

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Alterations of the retinoic acid receptor α (RARα) gene in myeloid and lymphoid malignancies

Abstract

UN SDGs

Keywords

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