An endoscopic system for gene & drug delivery directly to intraluminal tissue

Declan M. Soden; M. Sadadcharam; J. Piggott; A. Morrissey; C. G. Collins; G. C. O’Sullivan

doi:10.1007/978-3-540-73044-6_161

An endoscopic system for gene & drug delivery directly to intraluminal tissue

Declan M. Soden
, M. Sadadcharam
, J. Piggott
, A. Morrissey
, C. G. Collins
, G. C. O’Sullivan

Office of the Vice President for Research and Innovation

University College Cork

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

Abstract

Electrochemotherapy has been established in preclinical and clinical studies as an effective therapy; however, the currently available technology for delivery of this treatment is limited to surface tumours and is reliant on macroelectrodes such as callipers and needles. Internal cancers are not currently amenable to electrochemotherapy. If it were possible to deliver permeabilising electric pulses to intraluminal gastrointestinal or urinary tract tumours endoscopically, or to intra-abdominal tumours via the laparoscopic approach, many cancers which are now deemed inoperable or which are unresponsive to conventional therapies would become accessible to electrochemotherapy. Tumour reduction or regression would be a feasible aim, facilitating the achievement of palliation of symptoms, improved quality of life, prolonged survival and ultimately cure.

Original language	English
Title of host publication	IFMBE Proceedings
Editors	Tomaz Jarm, Peter Kramar, Anze zupanic
Publisher	Springer Verlag
Pages	628
Number of pages	1
Edition	1
ISBN (Print)	9783540730439
DOIs	https://doi.org/10.1007/978-3-540-73044-6_161
Publication status	Published - 2007
Event	11th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2007 - Ljubljana, Slovenia Duration: 26 Jun 2007 → 30 Jun 2007

Publication series

Name	IFMBE Proceedings
Number	1
Volume	16
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Conference

Conference	11th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2007
Country/Territory	Slovenia
City	Ljubljana
Period	26/06/07 → 30/06/07

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Electrochemotherapy
Electroporation
Endoscope
Gene therapy

Access to Document

10.1007/978-3-540-73044-6_161

Cite this

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title = "An endoscopic system for gene \& drug delivery directly to intraluminal tissue",

abstract = "Electrochemotherapy has been established in preclinical and clinical studies as an effective therapy; however, the currently available technology for delivery of this treatment is limited to surface tumours and is reliant on macroelectrodes such as callipers and needles. Internal cancers are not currently amenable to electrochemotherapy. If it were possible to deliver permeabilising electric pulses to intraluminal gastrointestinal or urinary tract tumours endoscopically, or to intra-abdominal tumours via the laparoscopic approach, many cancers which are now deemed inoperable or which are unresponsive to conventional therapies would become accessible to electrochemotherapy. Tumour reduction or regression would be a feasible aim, facilitating the achievement of palliation of symptoms, improved quality of life, prolonged survival and ultimately cure.",

keywords = "Cancer, Electrochemotherapy, Electroporation, Endoscope, Gene therapy",

author = "Soden, \{Declan M.\} and M. Sadadcharam and J. Piggott and A. Morrissey and Collins, \{C. G.\} and O{\textquoteright}Sullivan, \{G. C.\}",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag Berlin Heidelberg 2007.; 11th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2007 ; Conference date: 26-06-2007 Through 30-06-2007",

year = "2007",

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language = "English",

isbn = "9783540730439",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

number = "1",

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editor = "Tomaz Jarm and Peter Kramar and Anze zupanic",

booktitle = "IFMBE Proceedings",

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edition = "1",

}

Soden, DM, Sadadcharam, M, Piggott, J, Morrissey, A, Collins, CG & O’Sullivan, GC 2007, An endoscopic system for gene & drug delivery directly to intraluminal tissue. in T Jarm, P Kramar & A zupanic (eds), IFMBE Proceedings. 1 edn, IFMBE Proceedings, no. 1, vol. 16, Springer Verlag, pp. 628, 11th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2007, Ljubljana, Slovenia, 26/06/07. https://doi.org/10.1007/978-3-540-73044-6_161

An endoscopic system for gene & drug delivery directly to intraluminal tissue. / Soden, Declan M.; Sadadcharam, M.; Piggott, J. et al.
IFMBE Proceedings. ed. / Tomaz Jarm; Peter Kramar; Anze zupanic. 1. ed. Springer Verlag, 2007. p. 628 (IFMBE Proceedings; Vol. 16, No. 1).

Research output: Chapter in Book/Report/Conference proceedings › Conference proceeding › peer-review

TY - GEN

T1 - An endoscopic system for gene & drug delivery directly to intraluminal tissue

AU - Soden, Declan M.

AU - Sadadcharam, M.

AU - Piggott, J.

AU - Morrissey, A.

AU - Collins, C. G.

AU - O’Sullivan, G. C.

N1 - Publisher Copyright: © Springer-Verlag Berlin Heidelberg 2007.

PY - 2007

Y1 - 2007

N2 - Electrochemotherapy has been established in preclinical and clinical studies as an effective therapy; however, the currently available technology for delivery of this treatment is limited to surface tumours and is reliant on macroelectrodes such as callipers and needles. Internal cancers are not currently amenable to electrochemotherapy. If it were possible to deliver permeabilising electric pulses to intraluminal gastrointestinal or urinary tract tumours endoscopically, or to intra-abdominal tumours via the laparoscopic approach, many cancers which are now deemed inoperable or which are unresponsive to conventional therapies would become accessible to electrochemotherapy. Tumour reduction or regression would be a feasible aim, facilitating the achievement of palliation of symptoms, improved quality of life, prolonged survival and ultimately cure.

AB - Electrochemotherapy has been established in preclinical and clinical studies as an effective therapy; however, the currently available technology for delivery of this treatment is limited to surface tumours and is reliant on macroelectrodes such as callipers and needles. Internal cancers are not currently amenable to electrochemotherapy. If it were possible to deliver permeabilising electric pulses to intraluminal gastrointestinal or urinary tract tumours endoscopically, or to intra-abdominal tumours via the laparoscopic approach, many cancers which are now deemed inoperable or which are unresponsive to conventional therapies would become accessible to electrochemotherapy. Tumour reduction or regression would be a feasible aim, facilitating the achievement of palliation of symptoms, improved quality of life, prolonged survival and ultimately cure.

KW - Cancer

KW - Electrochemotherapy

KW - Electroporation

KW - Endoscope

KW - Gene therapy

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U2 - 10.1007/978-3-540-73044-6_161

DO - 10.1007/978-3-540-73044-6_161

M3 - Conference proceeding

AN - SCOPUS:85007047149

SN - 9783540730439

T3 - IFMBE Proceedings

SP - 628

BT - IFMBE Proceedings

A2 - Jarm, Tomaz

A2 - Kramar, Peter

A2 - zupanic, Anze

PB - Springer Verlag

T2 - 11th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2007

Y2 - 26 June 2007 through 30 June 2007

ER -

An endoscopic system for gene & drug delivery directly to intraluminal tissue

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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