An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas

Finbarr O'Sullivan; Janet Eary; Supratik Roy; Janet O'Sullivan; Cheryl Vernon

An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas

Finbarr O'Sullivan
, Janet Eary
, Supratik Roy
, Janet O'Sullivan
, Cheryl Vernon

School of Mathematical Sciences

University of Washington

Research output: Contribution to conference › Paper › peer-review

Abstract

Local heterogeneity is an important descriptor of the biological behavior of normal and pathological tissue. The most widely used measure of heterogeneity is relative dispersion(RD)(Kendal, PNAS, 2001). Because relative dispersion is spatially invariant it cannot distinguish alternative spatial patterns in the structure of heterogeneity. In previous work with FDG PET studies of human sarcomas a measure of spatial heterogeneity was developed that is based on the deviation of the distribution of the standardized FDG uptake (SUV image) from a unimodal elliptically contoured spatial pattern(O'Sullivan et al, SNM, 2001). This paper reports studies carried out to evaluate the statistical reliability and performance characteristics of this heterogeneity measure.

Original language	English
Pages	1131-1134
Number of pages	4
Publication status	Published - 2002
Event	2002 IEEE Nuclear Science Symposium Conference Record - Norfolk, VA, United States Duration: 10 Nov 2002 → 16 Nov 2002

Conference

Conference	2002 IEEE Nuclear Science Symposium Conference Record
Country/Territory	United States
City	Norfolk, VA
Period	10/11/02 → 16/11/02

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Elliptical model
Fluoro-deoxyglucose
Heterogeneity
Human sarcoma
Positron emission tomography
Spatial statistics
Survival analysis

Cite this

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title = "An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas",

abstract = "Local heterogeneity is an important descriptor of the biological behavior of normal and pathological tissue. The most widely used measure of heterogeneity is relative dispersion(RD)(Kendal, PNAS, 2001). Because relative dispersion is spatially invariant it cannot distinguish alternative spatial patterns in the structure of heterogeneity. In previous work with FDG PET studies of human sarcomas a measure of spatial heterogeneity was developed that is based on the deviation of the distribution of the standardized FDG uptake (SUV image) from a unimodal elliptically contoured spatial pattern(O'Sullivan et al, SNM, 2001). This paper reports studies carried out to evaluate the statistical reliability and performance characteristics of this heterogeneity measure.",

keywords = "Elliptical model, Fluoro-deoxyglucose, Heterogeneity, Human sarcoma, Positron emission tomography, Spatial statistics, Survival analysis",

author = "Finbarr O'Sullivan and Janet Eary and Supratik Roy and Janet O'Sullivan and Cheryl Vernon",

year = "2002",

language = "English",

pages = "1131--1134",

note = "2002 IEEE Nuclear Science Symposium Conference Record ; Conference date: 10-11-2002 Through 16-11-2002",

}

O'Sullivan, F, Eary, J, Roy, S, O'Sullivan, J & Vernon, C 2002, 'An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas', Paper presented at 2002 IEEE Nuclear Science Symposium Conference Record, Norfolk, VA, United States, 10/11/02 - 16/11/02 pp. 1131-1134.

An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas. / O'Sullivan, Finbarr; Eary, Janet; Roy, Supratik et al.
2002. 1131-1134 Paper presented at 2002 IEEE Nuclear Science Symposium Conference Record, Norfolk, VA, United States.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas

AU - O'Sullivan, Finbarr

AU - Eary, Janet

AU - Roy, Supratik

AU - O'Sullivan, Janet

AU - Vernon, Cheryl

PY - 2002

Y1 - 2002

N2 - Local heterogeneity is an important descriptor of the biological behavior of normal and pathological tissue. The most widely used measure of heterogeneity is relative dispersion(RD)(Kendal, PNAS, 2001). Because relative dispersion is spatially invariant it cannot distinguish alternative spatial patterns in the structure of heterogeneity. In previous work with FDG PET studies of human sarcomas a measure of spatial heterogeneity was developed that is based on the deviation of the distribution of the standardized FDG uptake (SUV image) from a unimodal elliptically contoured spatial pattern(O'Sullivan et al, SNM, 2001). This paper reports studies carried out to evaluate the statistical reliability and performance characteristics of this heterogeneity measure.

AB - Local heterogeneity is an important descriptor of the biological behavior of normal and pathological tissue. The most widely used measure of heterogeneity is relative dispersion(RD)(Kendal, PNAS, 2001). Because relative dispersion is spatially invariant it cannot distinguish alternative spatial patterns in the structure of heterogeneity. In previous work with FDG PET studies of human sarcomas a measure of spatial heterogeneity was developed that is based on the deviation of the distribution of the standardized FDG uptake (SUV image) from a unimodal elliptically contoured spatial pattern(O'Sullivan et al, SNM, 2001). This paper reports studies carried out to evaluate the statistical reliability and performance characteristics of this heterogeneity measure.

KW - Elliptical model

KW - Fluoro-deoxyglucose

KW - Heterogeneity

KW - Human sarcoma

KW - Positron emission tomography

KW - Spatial statistics

KW - Survival analysis

UR - https://www.scopus.com/pages/publications/0142210165

M3 - Paper

AN - SCOPUS:0142210165

SP - 1131

EP - 1134

T2 - 2002 IEEE Nuclear Science Symposium Conference Record

Y2 - 10 November 2002 through 16 November 2002

ER -

An Examination of the Statistical Reliability and Prognostic Potential of a Measure of 3-D Spatial Heterogeneity Developed for Volumetric PET Images of Human Sarcomas

Abstract

Conference

UN SDGs

Keywords

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