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The benefits of applying process analytical technology (PAT) in active pharmaceutical ingredient manufacture were studied. Mid-IR spectroscopy is a standard PAT technique that is often used to track chemical reactions. Spectra were acquired every minute over a 24-hour nominal batch time and multiple batches were monitored. At the start of phase A, the reaction vessel was loaded with the batch solvent, then the starting material, the other reagents followed, then the second reagent was metered into the vessel. Correct interpretation of the analytical data can reveal detailed reaction trajectories. Further in-situ measurements can evaluate the behavior of reactive intermediates, which is difficult though sampling chromatographic assay. The reaction profiles also indicate times when the reaction rates are low and this might be used to reduce the times allocated for each stage during manufacture and therefore increase the effectiveness of the reaction.