Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients

Finbarr O'Sullivan; Janet N. O'Sullivan; Jian Huang; Robert Doot; Mark Muzi; Erin Schubert; Lanell Peterson; Lisa K. Dunnwald; David M. Mankoff

doi:10.1117/1.JMI.5.1.011010

Assessment of a statistical AIF extraction method for dynamic PET studies with ¹⁵O water and ¹⁸F fluorodeoxyglucose in locally advanced breast cancer patients

Finbarr O'Sullivan
, Janet N. O'Sullivan
, Jian Huang
, Robert Doot
, Mark Muzi
, Erin Schubert
, Lanell Peterson
, Lisa K. Dunnwald
, David M. Mankoff

School of Mathematical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Blood flow-metabolism mismatch from dynamic positron emission tomography (PET) studies with O15-labeled water (H2O) and F18-labeled fluorodeoxyglucose (FDG) has been shown to be a promising diagnostic for locally advanced breast cancer (LABCa) patients. The mismatch measurement involves kinetic analysis with the arterial blood time course (AIF) as an input function. We evaluate the use of a statistical method for AIF extraction (SAIF) in these studies. Fifty three LABCa patients had dynamic PET studies with H2O and FDG. For each PET study, two AIFs were recovered, an SAIF extraction and also a manual extraction based on a region of interest placed over the left ventricle (LV-ROI). Blood flow-metabolism mismatch was obtained with each AIF, and kinetic and prognostic reliability comparisons were made. Strong correlations were found between kinetic assessments produced by both AIFs. SAIF AIFs retained the full prognostic value, for pathologic response and overall survival, of LV-ROI AIFs.

Original language	English
Article number	011010
Journal	Journal of Medical Imaging
Volume	5
Issue number	1
DOIs	https://doi.org/10.1117/1.JMI.5.1.011010
Publication status	Published - 1 Jan 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

AIF extraction
blood flow-metabolism mismatch
breast cancer
kinetic analysis
physiologically based pharmacokinetic model
positron emission tomography

Access to Document

10.1117/1.JMI.5.1.011010

https://hdl.handle.net/10468/6473Licence: CC BY

Cite this

O'Sullivan, F., O'Sullivan, J. N., Huang, J., Doot, R., Muzi, M., Schubert, E., Peterson, L., Dunnwald, L. K., & Mankoff, D. M. (2018). Assessment of a statistical AIF extraction method for dynamic PET studies with ¹⁵O water and ¹⁸F fluorodeoxyglucose in locally advanced breast cancer patients. Journal of Medical Imaging, 5(1), Article 011010. https://doi.org/10.1117/1.JMI.5.1.011010

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abstract = "Blood flow-metabolism mismatch from dynamic positron emission tomography (PET) studies with O15-labeled water (H2O) and F18-labeled fluorodeoxyglucose (FDG) has been shown to be a promising diagnostic for locally advanced breast cancer (LABCa) patients. The mismatch measurement involves kinetic analysis with the arterial blood time course (AIF) as an input function. We evaluate the use of a statistical method for AIF extraction (SAIF) in these studies. Fifty three LABCa patients had dynamic PET studies with H2O and FDG. For each PET study, two AIFs were recovered, an SAIF extraction and also a manual extraction based on a region of interest placed over the left ventricle (LV-ROI). Blood flow-metabolism mismatch was obtained with each AIF, and kinetic and prognostic reliability comparisons were made. Strong correlations were found between kinetic assessments produced by both AIFs. SAIF AIFs retained the full prognostic value, for pathologic response and overall survival, of LV-ROI AIFs.",

keywords = "AIF extraction, blood flow-metabolism mismatch, breast cancer, kinetic analysis, physiologically based pharmacokinetic model, positron emission tomography",

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O'Sullivan, F, O'Sullivan, JN, Huang, J, Doot, R, Muzi, M, Schubert, E, Peterson, L, Dunnwald, LK & Mankoff, DM 2018, 'Assessment of a statistical AIF extraction method for dynamic PET studies with ¹⁵O water and ¹⁸F fluorodeoxyglucose in locally advanced breast cancer patients', Journal of Medical Imaging, vol. 5, no. 1, 011010. https://doi.org/10.1117/1.JMI.5.1.011010

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AU - O'Sullivan, Finbarr

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AU - Doot, Robert

AU - Muzi, Mark

AU - Schubert, Erin

AU - Peterson, Lanell

AU - Dunnwald, Lisa K.

AU - Mankoff, David M.

N1 - Publisher Copyright: © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

PY - 2018/1/1

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N2 - Blood flow-metabolism mismatch from dynamic positron emission tomography (PET) studies with O15-labeled water (H2O) and F18-labeled fluorodeoxyglucose (FDG) has been shown to be a promising diagnostic for locally advanced breast cancer (LABCa) patients. The mismatch measurement involves kinetic analysis with the arterial blood time course (AIF) as an input function. We evaluate the use of a statistical method for AIF extraction (SAIF) in these studies. Fifty three LABCa patients had dynamic PET studies with H2O and FDG. For each PET study, two AIFs were recovered, an SAIF extraction and also a manual extraction based on a region of interest placed over the left ventricle (LV-ROI). Blood flow-metabolism mismatch was obtained with each AIF, and kinetic and prognostic reliability comparisons were made. Strong correlations were found between kinetic assessments produced by both AIFs. SAIF AIFs retained the full prognostic value, for pathologic response and overall survival, of LV-ROI AIFs.

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