Abstract
The chapter focuses on biologically active heterocyclic compounds in which the key step is an asymmetric 1,3-dipolar cycloaddition with an acrylamide. The use of chiral acrylamides as dipolarophiles leads to high levels of stereocontrol, due to conformational constraint in the acrylamides. Employment of chiral tertiary acrylamides containing nitrogen heterocycles is particularly effective in controlling the stereoselectivity.
| Original language | English |
|---|---|
| Title of host publication | Bioactive Heterocycles |
| Subtitle of host publication | Synthesis and Biological Evaluation |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 135-156 |
| Number of pages | 22 |
| ISBN (Print) | 9781622576364 |
| Publication status | Published - Jan 2013 |